ArticleFrontiers in public health2025
Age-period-cohort analysis of global, regional, and national trends in laryngeal Cancer among older adults, 1990-2021: insights from the 2021 global burden of disease study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progression by regulating PI3K/AKT-dependent glycolytic reprogramming.Cancer biology & therapy · 2026Article
- Global, regional, and national burden of influenza-associated lower respiratory infections, 1990-2021: a systematic analysis from the Global Burden of Disease Study 2021.BMC infectious diseases · 2026Article
- Trends and Drivers of Head and Neck Cancers in Older Adults Over 30 Years: A Population-Based Modelling Study.Risk management and healthcare policy · 2026Article
- The global, regional, and national impact of laryngeal cancer from 1990 to 2021, along with forecasts for 2050: a comprehensive analysis for the Global Burden of Disease 2021 research.Frontiers in oncology · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Background: Laryngeal cancer poses a significant health burden among older adults, with varying incidence, mortality, and disability-adjusted life years (DALYs) across regions. These disparities highlight the need for targeted interventions and tailored healthcare policies. Objectives: To analyze global, regional, and national trends in laryngeal cancer incidence, mortality, and DALYs among older adults from 1990 to 2021 using age-period-cohort modeling and to assess the impact of demographic factors on disease burden across socio-developmental index (SDI) regions. Materials and methods: Using the 2021 Global Burden of Diseases (GBD) database, trends in age-standardized incidence rates (ASIR), age-standardized mortality rates (ASMR), and age-standardized DALYs rates (ASDR) were analyzed, with a focus on the impact of population growth and aging across SDI regions. Age-period-cohort and Joinpoint regression analyses were conducted to identify temporal trends and critical inflection points across SDI quintiles. Results: From 1990 to 2021, the global ASIR of laryngeal cancer among older adults decreased from 15.16 to 12.25 per 100,000, with significant shifts in trends observed in 1995, 2002, and 2007. The disease burden in lowand middle SDI regions has declined relatively slower compared to high SDI regions, primarily driven by population growth. Conclusions and significance: Laryngeal cancer trends highlight the need for targeted healthcare interventions. Low and middle SDI areas require improved access to care and prevention strategies, while high SDI regions benefit from personalized, geriatric-focused care.
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