ArticleChemical engineering journal (Lausanne, Switzerland : 1996)2025
The Permanganate-Oxalate Reaction as a Visual Time-Temperature Indicator: Reaction Systems for Use Above 0 °C.
Article in Chemical engineering journal (Lausanne, Switzerland : 1996), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Kinetically Tunable, Subzero-Active, Visual Time-Temperature Indicators Based on the Permanganate-Oxalate Reaction.Reaction chemistry & engineering · 2025Article
- The Permanganate-Oxalate Reaction as a Visual Time-Temperature Indicator: Reaction Systems for Use Above 0 °C.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Biological molecules are often unstable at non-ideal temperatures, causing product inefficacy or false leads in research. Cost-effective, easily implemented tools are needed to ensure the quality of biological products and specimens requiring cold storage. Here, we developed a series of inexpensive visual time-temperature indicators (TTIs) based on the autocatalytic permanganate/oxalate reaction. This reaction transitions from intense pink to colorless in a non-linear manner, preserving color for an extended period followed by rapid decolorization, making it ideal for TTIs. Through extensive modeling and experimentation, TTIs were formulated that run for predefined periods at temperatures from 0 °C to 25 °C. They exhibited high run-time accuracy and reproducibility, with intra-batch and inter-batch run time precisions of ≤ 4.0% and ≤ 6.8% CV, respectively, at targeted temperatures. Average intra-batch and inter-batch absorbance vs. time trajectories, expressed as RMSD %CVs were 5.1% and 9.6%, respectively. The TTIs displayed temperature sensitivity consistent with Arrhenius behavior, making them suitable for monitoring biomolecular stability during temperature fluctuations. Pre-activation stability tests demonstrated the stability of solution components (excluding activating KMnO
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Registered trials
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