ReviewAnnals of medicine and surgery (2012)2025
The neurobiological impact of oxytocin in mental health disorders: a comprehensive review.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oxytocin dysfunction in severe mental illnesses following adverse childhood experiences: a systematic review.BMC psychiatry · 2026Pooled it
- Feasibility study examining the short-term effects of Sonic Augmentation Technology™.Frontiers in psychiatry · 2026Trial
- Neuropsychological and metabolic interconnectivity in obesity, anorexia and bulimia nervosa - an integrative literature review.Metabolic brain disease · 2026Review
- Methylome-Wide Association Studies of Physical Injury Stratified by Depression Status Assesses Exposure by Diagnosis Effects in Oxytocin Signaling and Synaptic Plasticity.Biological psychiatry global open science · 2026Article
- From Molecules to Meaning: Integrating Neuropeptides, Sociostasis, and Hormesis in the Brain-Heart Axis.Current issues in molecular biology · 2026Review
- Altered acetylcholine modulations and corticoaccumbal pathway in P11-linked social dysfunction.Molecular psychiatry · 2026Article
- Oxytocin Deficiency in Childhood and Adolescence: Clinical Features, Diagnostic Challenges and Therapeutic Perspectives.Current issues in molecular biology · 2025Review
- Beyond Latency: ChronicBiomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin, a neuropeptide, plays a significant role in modulating social behavior and has been widely studied for its potential impact on mental health disorders. This review examines the neurobiological mechanisms through which oxytocin influences mental health and its therapeutic potential in conditions such as autism spectrum disorder, schizophrenia, post-traumatic stress disorder, anxiety, and depression. Oxytocin enhances social bonding, trust, and empathy by modulating neural circuits linked to social interactions. Studies indicate that oxytocin's ability to regulate the hypothalamic-pituitary-adrenal axis plays a vital role in stress response and emotional regulation. Therapeutic applications, particularly intranasal administration of oxytocin, have shown promise in alleviating symptoms and improving patient outcomes. However, personalized approaches are essential to optimize treatment effectiveness. Despite its potential, challenges remain in understanding the mechanisms underlying its effects and identifying the patient populations that would benefit most from such therapies. Future research should focus on elucidating these mechanisms, exploring the long-term efficacy of oxytocin-based interventions, and advancing personalized medicine to maximize its clinical utility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.