ArticleAnnals of medicine and surgery (2012)2025
Effectiveness of intravenous lidocaine in treatment of burn pain: a systematic review and meta-analysis of randomzed controlled trials.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [A compulsory course in clinical treatment of burn patients: pain and analgesia].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Burns are among the most agonizing injuries encountered in the clinical setting. Protocols for effective management of burn pain vary and mostly rely on opioids, a drug class well-known for dependence and adverse effects from misuse. Lidocaine, the most commonly used local anesthetic, has shown potential to reduce the amount of opioids required. This study aims to assess the effectiveness of lidocaine infusion in reducing opioid use in patients with burn injuries. Methods: This systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of the electronic databases was carried out using the keywords "lidocaine," "lignocaine," "xylocaine," "burn," and "analgesia." Eligible studies were randomized controlled trials (RCTs) from peer-reviewed journals or registries. Two independent reviewers conducted the screening. The Cochrane Risk of Bias-2 tool was used to assess the quality of the included studies. Meta-analysis was conducted using Revman software. Results: We included four RCTs with 152 burn patients with the total body surface area burned ranging from 3% to 68%. Morphine use had a standardized mean difference (SMD) of -0.47 (-1.18 to 0.24), which was not significant ( Conclusion: Our findings were inconclusive about the safety and effectiveness of lidocaine as an adjunct in the analgesia of burns and reducing the required opioid dosage. Large-scale clinical trials are needed.
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Registered trials
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