Evidence map›Paper›PMID 40213146›Full record

ArticleFrontiers in physiology2025

Dual role of calcium-activated potassium channels of high conductance: facilitator or limiter of NO-induced arterial relaxation?

Anastasia A Shvetsova, Dina K Gaynullina, Johannes Schmid, Peter Winkler, Isabella Sonsala, Rudolf Schubert

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Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anastasia A Shvetsova *Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia.
Dina K Gaynullina *Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia.
Johannes SchmidPhysiology, Faculty of Medicine, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.
Peter WinklerPhysiology, Faculty of Medicine, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.
Isabella SonsalaPhysiology, Faculty of Medicine, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.
Rudolf SchubertPhysiology, Faculty of Medicine, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Calcium-activated potassium channels of high conductance (BK Methods: Contractile responses of rat tail, saphenous, and left and right coronary arteries were studied using wire myography. Results: The NO-donor SNP reduced contractile responses induced by low concentrations of methoxamine or serotonin, respectively, in all arteries tested, both in the absence and in the presence of iberiotoxin. This anticontractile effect of SNP was larger in the presence of iberiotoxin than in its absence, i.e., functionally active BK Conclusion: BK

Indexed as

arterial smooth muscleBK channelcoronary arteriesnitric oxidesaphenous arterytail arteryvasodilation

Identifiers

PMID40213146
PMCPMC11983649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.