Evidence map›Paper›PMID 40213013›Full record

ArticleUrology case reports2025

Durable disease control with cabozantinib in metastatic chromophobe renal cell carcinoma: A rare case with promising outcomes.

Seif Haddaoui, Yosra Berrazega, Nesrine Mejri, Myriam Saadi, Ahmed Anas Haouari, Alia Zehani, Haifa Rachdi

Abstract readCase Reports
In one paragraph

Article in Urology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seif HaddaouiUniversity Tunis El Manar, Faculty of medicine Tunis, Medical oncology department, Abderrahmen Mami Hospital, Tunisia.
Yosra BerrazegaUniversity Tunis El Manar, Faculty of medicine Tunis, Medical oncology department, Abderrahmen Mami Hospital, Tunisia.
Nesrine MejriUniversity Tunis El Manar, Faculty of medicine Tunis, Medical oncology department, Abderrahmen Mami Hospital, Tunisia.
Myriam SaadiUniversity Tunis El Manar, Faculty of medicine Tunis, Medical oncology department, Abderrahmen Mami Hospital, Tunisia.
Ahmed Anas HaouariUniversity Tunis El Manar, Faculty of medicine Tunis, Medical oncology department, Abderrahmen Mami Hospital, Tunisia.
Alia ZehaniUniversity Tunis El Manar, Faculty of medicine Tunis, Pathology department, Rabta Hospital, Tunisia.
Haifa RachdiUniversity Tunis El Manar, Faculty of medicine Tunis, Medical oncology department, Abderrahmen Mami Hospital, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromophobe renal cell carcinoma (chRCC) is a rare RCC subtype with limited treatment data. Cabozantinib, a multikinase inhibitor, is effective in clear cell RCC but lacks robust evidence in chRCC. A 26-year-old male with metastatic chRCC achieved prolonged disease control on cabozantinib despite treatment interruptions. After first-line pazopanib failure, cabozantinib was initiated in January 2023, maintaining stable disease for over two years with only grade I toxicities. Cabozantinib appears effective in metastatic chRCC, offering prolonged stability with manageable toxicity. Further research is needed to establish its role in this rare RCC subtype.

Indexed as

CabozantinibChromophobe renal cell carcinomaMetastasis

Identifiers

PMID40213013
PMCPMC11982476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.