Evidence map›Paper›PMID 40212936›Full record

ArticleOphthalmology science

Heterogeneous Visual Function Deficits in Intermediate Age-Related Macular Degeneration: A MACUSTAR Report.

Hannah M P Dunbar, David P Crabb, Charlotte Behning, Alison M Binns, Amina Abdirahman, Jan H Terheyden, Stephen Poor, Robert P Finger, Sergio Leal, Adnan Tufail and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Review
  3. Observational
  4. Article
  5. Review
  6. The Spectrum of Functional, Structural, and Patient-Reported Outcomes in Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hannah M P DunbarInstitute of Ophthalmology, London, UK.
David P CrabbCity University of London, London, UK.
Charlotte BehningMedical Faculty, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
Alison M BinnsCity University of London, London, UK.
Amina AbdirahmanInstitute of Ophthalmology, London, UK.
Jan H TerheydenCity University of London, London, UK.
Stephen PoorNovartis Pharma, Cambridge.
Robert P FingerDepartment of Ophthalmology, Mannheim University Hospital, Heidelberg University, Mannheim, Germany.
Sergio LealBayer Consumer Care AG, Basel, Switzerland.
Adnan TufailInstitute of Ophthalmology, London, UK.
Frank G HolzDepartment of Ophthalmology, University Hospital Bonn, Bonn, Germany.
Matthias SchmidMedical Faculty, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
Ulrich F O LuhmannRoche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center Basel, Basel, Switzerland.
MACUSTAR Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To examine the extent to which visual function in Beckman age-related macular degeneration (AMD) disease stages differs from age-similar peers with no AMD and, using reference limits derived from those with no AMD, test the hypothesis that people with intermediate AMD (iAMD) have heterogeneous visual function deficits. Design: Cross-sectional analyses of a range of baseline visual function measures from the MACUSTAR study-an international, multicenter (n = 20), noninterventional clinical trial. Participants: Five hundred eighty-five participants with iAMD (67% female, mean [standard deviation] age 72 [7] years) were recruited alongside 56 with no AMD (59% female, 68 [6]), 34 with early AMD (79% female, 72 [6]), and 43 with late AMD (49% female, 75 [6]). Methods: Participants performed best-corrected visual acuity (BCVA), low luminance visual acuity (LLVA), Moorfields acuity test (MAT), Pelli-Robson contrast sensitivity (PR-CS), small print standardized International reading speed test (SPS), mesopic and scotopic average threshold (MesAT and ScoAT; macular integrity assessment, iCare), and rod intercept time (RIT; AdaptDx, Lumithera). Main Outcome Measures: Relationship between each visual function measure and disease classification was examined by linear regression adjusted for age, sex, and phakic status. No AMD data were used to estimate normal reference limits for each visual function test. Intermediate AMD scores were dichotomized against reference limits, and the proportion worse than each limit was calculated. Results: Relative to no AMD, SPS was significantly worse in early AMD ( Conclusions: A large proportion of people with structurally defined iAMD exhibit heterogeneous visual function deficits outside normal reference limits. This observation may be relevant for the design and inclusion criteria of future interventional trials. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Age-related macular degenerationVisual dysfunctionVisual function

Identifiers

PMID40212936
PMCPMC11985047

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.