ArticleFrontiers in cellular and infection microbiology2025
Multi-omics assessment of gut microbiota in circadian rhythm disorders: a cross-sectional clinical study.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Circadian Regulation of Gut Microbial Metabolites in Intestinal Epithelial Homeostasis.Metabolites · 2026Review
- Chronobiome medicine: circadian regulation of host-microbiota crosstalk in systemic physiology.Frontiers in endocrinology · 2025Review
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Authors and funding
14 authors.
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Abstract
Background: The interaction between the host and microbiota is influenced by host circadian rhythm. However, it is unknown what the changes of gut microbiota and metabolites. Methods: We conducted a cross-sectional study (n=72) in which participants' fecal DNA was detected by macrogenomic sequencing analysis. The feces, urine and blood were analyzed by widely targeted metabolomics analysis. Results: Pearson correlation analysis showed that most of the clinical symptoms of people with circadian rhythm disorders were moderately positively correlated with gastrointestinal symptoms. By distilling the results of multinomic analysis, we reported a variety of different species (19 species in the gut) and metabolites. In our results, the correlation of multiomics is mostly concentrated in Discussion: Our study demonstrates the severity of clinical manifestations caused by circadian rhythm disorder is closely related to microbiota and metabolism. In the future, personalized interventions targeting specific microbial species or metabolites may help alleviate the physical and psychological discomfort induced by circadian rhythm disturbances.
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