ArticleFrontiers in nutrition2025
Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Aging reimagined: Bridging clinical modulation and scientific breakthroughs.Biology of sport · 2026Review
- Magnesium Depletion Score as an Indicator of Health Risk and Nutritional Status-A Scoping Review.Nutrients · 2025Article
- Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome.Diabetology & metabolic syndrome · 2025Review
- Magnesium depletion score is a risk factor for all-cause, cancer and cardiovascular disease mortality in cancer survivors: evidence from two prospective cohort studies.Frontiers in nutrition · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Magnesium deficiency and low levels of the anti-aging protein Klotho have been independently associated with various age-related diseases. The Magnesium Depletion Score (MDS) is recognized as a more valuable and reliable predictor of body magnesium status than traditional clinical markers such as serum and urine magnesium. However, the relationship between magnesium status and serum Klotho levels remains unexplored. This study aimed to investigate the association between magnesium depletion, as quantified by MDS, and serum Klotho levels in US adults. Methods: We analyzed data from 11,387 participants aged 40-79 years in the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Participants were divided into three groups based on MDS: low (0-1 points), middle (2 points), and high (3-5 points), reflecting cumulative risks of magnesium depletion derived from diuretic use, proton pump inhibitors, renal function, and alcohol intake. Serum Klotho levels were measured using a validated ELISA assay. Sample-weighted multivariable linear regression models were used to examine the association between MDS and serum Klotho levels, adjusting for age, sex, race, socioeconomic status, lifestyle factors (smoking, alcohol use), clinical parameters (body mass index, blood pressure, lipid levels), and energy intake. Results: The weighted average serum Klotho concentrations decreased significantly across MDS groups (low: 864.50, middle: 805.67, high: 755.02 pg./mL; Conclusion: This study provides novel evidence of an inverse association between MDS, a new valuable indicator of magnesium status, and serum Klotho levels in a large, representative sample of US adults. These findings suggest that monitoring magnesium status via MDS could help identify individuals at risk of accelerated aging, prompting interventions such as dietary adjustments or magnesium supplementation in high-risk populations. Further research is warranted to elucidate the mechanisms underlying this association and its implications for age-related diseases.
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