ArticleSmall science2022
A Microfluidic Approach for Quantitative Study of Spatial Heterogeneity in Bacterial Biofilms.
Article in Small science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Emerging Multimodal Strategies for Bacterial Biofilm Eradication: A Comprehensive Review.Microorganisms · 2025Review
- Microfluidics to Meet Antibiotic Resistance: A Growing Research Frontier.Antibiotics (Basel, Switzerland) · 2025Review
- Community-specific cell death sustains bacterial expansion under phosphorus starvation.Nature chemical biology · 2025Article
- Oxygen microenvironments inMicrobiology (Reading, England) · 2025Article
- Individual-based modeling unravels spatial and social interactions in bacterial communities.The ISME journal · 2025Review
- Essential phage component induces resistance of bacterial community.Science advances · 2024Article
- Spatially structured exchange of metabolites enhances bacterial survival and resilience in biofilms.Nature communications · 2024Article
- Community-specific diffusion characteristics determine resistance of biofilms to oxidative stress.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial biofilms play essential roles in ecological environments and in human health. The spatial heterogeneity of biofilms is crucial to their resistance and collective behavior, while quantitative analysis of these biofilm-specific features is limited. Here, a microfluidic approach is developed to address this issue. Through a special design of microfluidic chamber and spatially controllable bacteria seeding, biofilms are cultivated with customized semi-2D structure, which enables quantitative measurements of spatially heterogeneous features with time-lapse microscopy. The advantages of the proposed method are demonstrated via two examples on biofilm homeostasis and stress response, respectively, where the functionally important spatiotemporal dynamics is delineated. In homeostasis, it is found that
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.