ReviewFrontiers in pediatrics2024
Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress.
Review in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Assessing pedicle morphology in pediatric spinal deformity: can magnetic resonance imaging match computed tomography? A systematic review.Spine deformity · 2026Pooled it
- The use of robotic single site system in pediatric surgery: a systematic review.Journal of robotic surgery · 2025Pooled it
- Targeting the SIRT1-TLR4 axis attenuates oxidative inflammation in a cellular model of bronchopulmonary dysplasia.Pediatric research · 2026Article
- Machine learning-based prediction of pediatric scoliosis using foot pressure and body angles.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- MiR-203a-3p in extracellular vesicles derived from mesenchymal stem cells alleviates BPD-associated apoptosis and inflammation.Stem cell research & therapy · 2025Article
- Mitochondria as the central regulator of cell death in bronchopulmonary dysplasia.Frontiers in physiology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the global rise in preterm birth rates, bronchopulmonary dysplasia (BPD) continues to be a significant problem, affecting morbidity and mortality in surviving preterm infants. Preterm infants are particularly susceptible to oxidative stress induced by sudden increases in oxygen concentration, which plays a crucial role in the pathogenesis of BPD. Herein, we addressed the pathophysiologic mechanisms, clinical treatment, and predictive biomarkers of BPD from an oxidative stress perspective. We first review the importance of oxygen in preterm infants and point out that sustained exposure to hyperoxia exacerbates the susceptibility of the immature lung to free radicals. The antioxidant properties of clinical therapies for BPD in preterm infants are then summarized. Subsequently, based on lipid, protein, and DNA damage mechanisms, we obtained the most comprehensive, accurate, and representative oxidative stress biomarkers. A total of 37 research papers on oxidative stress in BPD were collected. We conclude that 8-OHdG is the most promising biomarker for early prediction of BPD pathogenesis compared to lipid and protein oxidative stress biomarkers.
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Registered trials
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