ReviewSmall science2025
Recent Advances in the Design and Structural/Functional Regulations of Biomolecule-Reinforced Graphene Materials for Bone Tissue Engineering Applications.
Review in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Surface-Engineered Magnetic Nanoparticles in Skeletal Muscle Tissue Engineering: From Biological Interactions to Clinical Translation.Micromachines · 2026Review
- Black phosphorus in theragenerative medicine: a multi-organ perspective on disease modulation and tissue repair.Bioactive materials · 2026Review
- Recent Advances in Integrating Graphene into Polymeric Nanocomposite Hydrogels for Biomedical Applications.Macromolecular bioscience · 2026Review
- A Multifunctional PEEK Composite Scaffold with Immunomodulatory, Angiogenic, and Osteogenic Properties for Enhanced Bone Regeneration.Polymers · 2025Article
- Biomedical Aerogels in Wound Healing: Therapeutic Strategies and Translational Insights.Biomaterials research · 2025Review
- Advancements in Nanomedicine for the Diagnosis and Treatment of Kidney Stones.International journal of nanomedicine · 2025Review
- Engineering Functional Graphenic Materials for Bone Repair.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomolecule-reinforced graphene materials (Bio-RGMs) have emerged as versatile matrices for biomedical and tissue engineering applications, owing to the combination of graphene-based materials (GMs) with biomolecular components and their synergistic effects. In this review, an overview of the design, synthesis, structural/functional regulation, and bone engineering applications of various Bio-RGMs is provided. Both covalent and noncovalent methods for conjugating biomolecules onto GMs, followed by an exploration of the structural diversity of Bio-RGMs, ranging from 1D nanofibers to 2D membranes and 3D scaffolds/hydrogels/aerogels are discussed. Techniques such as electrospinning, self-assembly, freeze-drying, 3D printing, and templated synthesis are highlighted for their roles in designing and fabricating Bio-RGM architectures. Additionally, specific properties and functions endowed to Bio-RGMs by biomolecule conjugation, including biocompatibility, cytotoxicity, antibacterial activity, drug delivery ability, and fluorescent sensing are examined. Finally, recent advance is showcased in fabricating Bio-RGMs for the bone tissue engineering applications of bone repair, regeneration, grafting, drug/cell delivery, and tumor inhibition, and further, the potential of Bio-RGMs for preclinical applications is analyzed. It is believed that this review will deepen readers' understanding of biomolecule-GM interactions and inspire the development of innovative Bio-RGMs for advanced biomedical and tissue engineering applications.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.