Plasmonic Coupling for High-Sensitivity Detection of Low Molecular Weight Molecules.

This article presents a novel plasmonic sensing platform designed for the detection of low molecular weight molecules, offering significant advancements in diagnostic applications. The platform features a periodic array of gold nanodisks on a 20 nm thin silica layer, supported by a 100 nm thick gold substrate. By leveraging the coupling between localized and propagating surface plasmon resonances, this design significantly enhances the sensitivity and specificity of molecular detection. Finite element method simulations are conducted to characterize the optical properties and reflectance response of the nanodisks array in the visible to near-infrared range. Ellipsometric analysis is performed to measure the reflectance of the sample at various angles. Additionally, scanning near-field optical microscopy in reflectance mode validates the design by revealing well-defined plasmonic hot spots and interference patterns consistent with the simulated results. The findings demonstrate the platform's effectiveness in amplifying optical signals, achieving a limit of detection of 50 μM for molecules with a molecular weight of less than 1 KDa. This high sensitivity and specificity highlight the potential of the proposed plasmonic platform to advance the development of highly sensitive sensors for low molecular weight molecules, making it a valuable tool for diagnostics and precise molecular detection.