ArticleSmall science2022
Single-Cell Motility Rapidly Quantifying Heteroresistance in Populations of
Article in Small science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Microfluidics to Meet Antibiotic Resistance: A Growing Research Frontier.Antibiotics (Basel, Switzerland) · 2025Review
- Integrated Microfluidics for Single-Cell Separation and On-Chip Analysis: Novel Applications and Recent Advances.Small science · 2024Article
- Capturing of extracellular vesicles derived from single cells ofLab on a chip · 2024Article
- Sensing of Antibiotic-Bacteria Interactions.Antibiotics (Basel, Switzerland) · 2023Review
- A Novel Hybrid Platform for Live/Dead Bacteria Accurate Sorting by On-Chip DEP Device.International journal of molecular sciences · 2023Article
- Single-cell pathogen diagnostics for combating antibiotic resistance.Nature reviews. Methods primers · 2023Article
- Relationships between Efflux Pumps and Emergence of Heteroresistance: A Comprehensive Study on the Current Findings.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneous bacterial populations can display increased resistance to external threats, such as exposure to antibiotics. Despite the mounting clinical evidence supporting the importance of bacterial heterogeneity in acute infections, current antimicrobial susceptibility tests (ASTs) are typically insensitive to cell-to-cell differences as they only measure population-wide averages. Herein, the use of single-cell motility to address this issue is demonstrated. It is shown for the first time that antibiotic susceptibility detected as a change in single-cell motility is an excellent proxy for polyclonal and monoclonal heteroresistance. It is also demonstrated that motility and growth are both inhibited by an antibiotic with strikingly similar patterns, thus enabling the quantification of minimum inhibitory concentration (MIC) using a high-throughput, single-cell motility assay. The method allows for the detection of heteroresistance in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.