Evidence map›Paper›PMID 40212594›Full record

ArticleiScience2025

The neural correlates of logical-mathematical symbol systems processing resemble those of spatial cognition more than language processing.

Yuannan Li, Shan Xu, Jia Liu

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuannan LiTsinghua Laboratory of Brain and Intelligence, Department of Psychological and Cognitive Sciences, Tsinghua University, Beijing 100086, China.
Shan XuFaculty of Psychology, Beijing Normal University, Beijing 100875, China.
Jia LiuTsinghua Laboratory of Brain and Intelligence, Department of Psychological and Cognitive Sciences, Tsinghua University, Beijing 100086, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to use logical-mathematical symbols (LMS), encompassing tasks such as calculation, reasoning, and programming, is special to humans with recent emergence. LMS processing was suggested to build upon fundamental cognitive systems through neuronal recycling, with natural language processing and spatial cognition as key candidates. This study used meta-analyses and synthesized neural maps of representative LMS tasks, including reasoning, calculation, and mental programming, to compare their neural correlates with those of the two systems. Our results revealed greater activation overlap and multivariate similarity between LMS and spatial cognition than with language processing. Hierarchical clustering further indicated that LMS tasks were indistinguishable from spatial tasks at the neural level, suggesting an inherent connection. Our findings support the hypothesis that spatial cognition is the basis of LMS processing, shedding light on the logical reasoning limitations of large language models, particularly those lacking explicit spatial representations.

Indexed as

Cognitive neuroscienceNeuroscience

Identifiers

PMID40212594
PMCPMC11985154

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.