ArticleSmall science2024
Magnetic Membranes for Cell Growth Under Curved and Reversible Deformations.
Article in Small science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Magnetic polymer composites are very versatile candidates to fabricate soft robots and actuators thanks to their unique properties such as flexibility and shape memory effect. Thus, the possibility to reproduce natural shapes provides new tools for bioengineering applications. The wide panel of deformations of magnetic polymer composites can be implemented to mimic the movements and curvatures of living tissue. Herein, magnetic polymer membranes are developed to explore cell growth under curved, reversible, and controlled deformations. NdFeB/polydimethylsiloxane composite membranes (86 μm and 46 μm thick) are obtained by soft lithography and magnetized in rolled position under 3 T. Once actuated by a low magnetic field (5-86 mT), the membranes are deformed in wavy shapes with a deformation height of maximum 1.4 and 1.7 mm and a curvature radius of minimum 1.8 and 0.6 mm (86 μm and 46 μm thick membranes, respectively), for a maximum magnetic field of 86 mT. Then, Caco-2 cell viability is studied on deformed substrates under a static (106 mT) and varying (8-78 mT) magnetic field. No increase in cell death is observed, validating a well-characterized and promising approach for a new generation of dynamic and curved substrates for cell culture.
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