ArticleSmall science2024
Light-Responsive Nanoantennas Integrated into Nanoscale Metal-Organic Frameworks for Photothermal Drug Delivery.
Article in Small science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Seeded-Growth of ZIF-8 onto Magnetic Nanoparticles: Smart Nanocarriers with Ultrahigh Drug Loading for AMF-Triggered Release.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Microbial Lignin Valorization to Protocatechuic Acid and Catechol: Biofunneling Pathways and Metabolic Engineering Strategies.Biomolecules · 2026Review
- Research Progress on Self-Assembling Delivery Systems in Rheumatoid Arthritis.International journal of nanomedicine · 2026Review
- Magnetoplasmonic Nanostructures from Magnetite with Noble Metal Surface Modification and Their Antimicrobial Activity.International journal of molecular sciences · 2025Article
- Harnessing light: Synthesis, mechanisms, and pre-clinical biomedical applications of stimuli-responsive multiscale composites.Materials today. Bio · 2025Review
- Clickable Polymer-Based Coatings for Modulating the Interaction of Metal-Organic Framework Nanocrystals with Living Cells.ACS applied materials & interfaces · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoscale metal-organic frameworks (NMOFs) exhibit unique properties for drug delivery, including ultrahigh storage capabilities, biocompatibility, biodegradability, and sustained release of encapsulated cargo. However, due to their localized electronic states, MOFs are nonresponsive to external stimuli such as light or magnetic fields. This study investigates the integration of light-responsive nanoantennas into NMOFs to enhance their application as smart drug delivery nanosystems. By integrating gold bipyramid nanoantennas within ZIF-8 and NU-1000 NMOFs, core@shell nanosystems are created with photothermal capabilities. Utilizing cresyl violet as a model drug, the loading and release dynamics of these nanosystems are analyzed, demonstrating controlled drug release under near-infrared (NIR) light stimulation. Photothermal release studies conducted in living cells reveal the potential of these nanocomposites for spatiotemporal targeted, light-activated drug delivery. Further evaluation of the NU-1000 nanocomposite loaded with chemotherapeutics-doxorubicin, carboplatin, and oxaliplatin-in both 2D and 3D cell cultures shows the nanosystem effectiveness in cell internalization and therapeutic NIR activation. The findings demonstrate that the incorporation of stimuli-responsive elements into NMOFs offers a promising approach for developing advanced drug delivery platforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.