ArticleFrontiers in microbiology2025
An AIE-active probe acts as novel tool for rapid and accurate quantitative antifungal susceptibility assessment.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Common antifungal susceptibility testing methods are often time-consuming and subject to interpretation bias in endpoint determination, making them inadequate for clinical applications. We aim to develop a rapid and accurate quantitative method for routine antifungal susceptibility testing in diagnostic laboratories by employing the aggregation-induced emission (AIE) luminogen TBP-2. Methods: The AIE luminogen TBP-2 with two positive charges was introduced to develop an antifungal susceptibility testing protocol based on the reference broth microdilution (BMD) method. The minimum inhibitory concentration of different drugs against Results: The TBP-2-based method enables endpoint determination by detecting fluorescence intensity after a co-incubation period of 8 h with Conclusion: The TBP-2-based method provides rapid and accurate quantifiable endpoints, aiding in the timely selection of appropriate antifungal therapy, and offering opportunities for automation and widespread application.
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