Evidence map›Paper›PMID 40212374›Full record

ArticlePeerJ2025

The gut microbiota in mice with erythropoietin-induced abdominal aortic aneurysm.

Xinyi Lyu, Mingjun Jiang, Jiahao Shi, Qi Liu, Xilian Liu, Yulan Li, Shu-Qin Ding, Xianpeng Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinyi Lyu *Department of Vascular Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Mingjun Jiang *Department of Vascular Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jiahao ShiDepartment of Vascular Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Qi LiuDepartment of Vascular Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Xilian LiuDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Yulan LiDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shu-Qin DingClinical Laboratory, The First Affiliated Hospital of Bengbu Medical University, Anhui University, Bengbu, Anhui, China.
Xianpeng DaiDepartment of Vascular Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In recent years, a novel animal abdominal aortic aneurysm (AAA) model was established by administering erythropoietin (EPO) to wild-type (WT) mice. However, the influence of EPO on the murine fecal microbiota remains uninvestigated. Therefore, this study aims to explore the potential association between gut microbiota changes and AAA development in this model. Methods and results: Adult male C57BL/6 mice were used to establish the AAA model by intraperitoneal administration of recombinant human EPO at a dosage of 10,000 IU/kg daily for 28 consecutive days. Hematoxylin and eosin (H&E) and Elastin Van Gieson (EVG) staining revealed that EPO administration increased aortic wall thickness and diameter, accompanied by enhanced degradation of the elastic lamina. The 16S rRNA-sequencing data were deposited in the Sequence Read Archive (PRJNA1172300). LEfSe analysis revealed that Conclusions: EPO-induced gut dysbiosis, particularly changes in

Indexed as

Aortic Aneurysm, AbdominalErythropoietinGastrointestinal MicrobiomeAnimalsDisease Models, AnimalFecesHumansMaleMiceMice, Inbred C57BLRNA, Ribosomal, 16SErythropoietinRNA, Ribosomal, 16S16S rRNA-sequencingAbdominal aortic aneurysmErythropoietinGut microbiota

Identifiers

PMID40212374
PMCPMC11984472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.