Evidence map›Paper›PMID 40212318›Full record

ReviewKidney medicine2025

Interventions to Improve Life Participation in Kidney Transplant Recipients: A Systematic Review.

Patrizia Natale, Angela Ju, Martin Howell, Germaine Wong, Armando Teixeira-Pinto, Anastasia Hughes, Chandana Guha, Amanda Sluiter, Nicole Scholes-Robertson, Jonathan C Craig and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Patrizia NataleSydney School of Public Health, The University of Sydney, Sydney, Australia.
Angela JuSydney School of Public Health, The University of Sydney, Sydney, Australia.
Martin HowellSydney School of Public Health, The University of Sydney, Sydney, Australia.
Germaine WongSydney School of Public Health, The University of Sydney, Sydney, Australia.
Armando Teixeira-PintoSydney School of Public Health, The University of Sydney, Sydney, Australia.
Anastasia HughesSydney School of Public Health, The University of Sydney, Sydney, Australia.
Chandana GuhaSydney School of Public Health, The University of Sydney, Sydney, Australia.
Amanda SluiterSydney School of Public Health, The University of Sydney, Sydney, Australia.
Nicole Scholes-RobertsonCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
Michelle A JosephsonDepartment of Medicine, University of Chicago, Chicago, IL.
Giovanni StrippoliSydney School of Public Health, The University of Sydney, Sydney, Australia.
Allison JaureSydney School of Public Health, The University of Sydney, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale & Objective: Life participation, defined as the ability to participate in meaningful activities of daily living, is a critically important outcome for kidney transplant recipients. We aimed to evaluate the effectiveness of any interventions on life participation in kidney transplant recipients. Study Design: A systematic review of randomized controlled studies. Study Populations: Adult kidney transplant recipients. Search Strategy & Sources: MEDLINE, Embase, CENTRAL, PsycINFO and CINAHL were searched up to March 2023. Data Extraction: Two authors independently screened titles and abstracts, and extracted data from the included studies using standard data extraction forms. Analytical Approach: We used random-effects models with relative risk for dichotomous outcomes and mean difference for continuous outcomes with 95% confidence intervals (CIs). Confidence in the evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Results: From 14,162 reports, only 33 studies (4,857 participants) were included. The risk of bias was adjudicated as high or unclear for most domains. No studies reported the outcome of life participation specifically. Among 33 studies, mental, physical and social functioning were reported in 5 (15%), 5 (15%), and 11 (33%) studies, respectively. Limitations: A wide range of interventions were included across the studies with a limited follow-up, and we were unable to pool the data and perform meta-analysis for outcomes that were reported in a single study only or in studies reporting no events. Conclusions: The effects of prebiotics, erythropoietin-stimulating agents, immunosuppressive treatments, induction therapy of interleukin-2 receptor antagonist, exercise, nutrition, education, and surgical procedures on life participation-related outcomes were uncertain. Life participation was not reported as a specific outcome in trials in kidney transplant recipients with very limited evidence on interventions for life participation-related outcomes. Trial-based evidence for interventions to improve life participation, a critical outcome for kidney transplant recipients, is needed.

Indexed as

Kidney transplantationlife participationquality of liferandomized controlled studysystematic review

Identifiers

PMID40212318
PMCPMC11982030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.