Evidence map›Paper›PMID 40212283›Full record

ArticleBrain, behavior, & immunity - health2025

Predictors of fatigue progression in long COVID among young people.

Elias Myrstad Brodwall, Joel Selvakumar, Lise Beier Havdal, Silke Sommen, Lise Lund Berven, Erin Cvejic, Vegard Bruun Bratholm Wyller, Maria Pedersen

Abstract read
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In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elias Myrstad BrodwallDept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.
Joel SelvakumarDept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.
Lise Beier HavdalDept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.
Silke SommenDept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.
Lise Lund BervenDept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.
Erin CvejicThe University of Sydney, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Australia.
Vegard Bruun Bratholm WyllerDept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.
Maria PedersenDept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long COVID, or post-COVID-19 condition (PCC), has emerged as a significant health concern, with fatigue being the most prevalent persistent symptom among young people. However, research on predictors of fatigue progression in young populations is limited. This study aimed to investigate factors during acute SARS-CoV-2 infection that could predict fatigue progression between six and 12 months post-infection in a cohort of young people with chronic fatigue following COVID-19. Data from the Long-Term Effects of COVID-19 in Adolescents (LoTECA) project were analyzed. A total of 93 participants (mean age 18.5 years, 84 % female) with chronic fatigue at six months, completed the 12-month follow-up. Multivariate analyses identified non-European ethnicity, higher interferon gamma (IFN-γ) levels, and lower RR-interval (higher resting heart rate) during acute infection as significant predictors of fatigue progression from six to 12 months. These three factors explained 21 % of the variance in the fatigue score, highlighting the importance of ethnicity, immune response, and autonomic function in the trajectory of long COVID fatigue. Early identification and targeted interventions, particularly for ethnic minorities and those with specific immune or autonomic markers during acute infection, may be helpful in reducing long-term fatigue. Further research is needed to explore treatment strategies for affected young populations.

Indexed as

AdolescentsChronic fatigueFatigue risk factorsFatigue trajectoryLong COVIDPost-COVID condition (PCC)Post-infective fatigue syndrome (PIFS)SARS-CoV-2

Identifiers

PMID40212283
PMCPMC11985126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.