Evidence map›Paper›PMID 40212250›Full record

ArticleSmall science2024

Accurate and Flexible Single Cell to Spatial Transcriptome Mapping with Celloc.

Wang Yin, Xiaobin Wu, Linxi Chen, You Wan, Yuan Zhou

Abstract read
In one paragraph

Article in Small science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wang YinDepartment of Biomedical Informatics School of Basic Medical Sciences Peking University 38 Xueyuan Road Beijing 100191 China.ORCID https://orcid.org/0009-0005-6250-3847
Xiaobin WuDepartment of Biomedical Informatics School of Basic Medical Sciences Peking University 38 Xueyuan Road Beijing 100191 China.
Linxi ChenKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital & Institute 52 Fucheng Road Beijing 100142 China.
You WanDepartment of Neurobiology School of Basic Medical Sciences Neuroscience Research Institute Peking University 38 Xueyuan Road Beijing 100191 China.
Yuan ZhouDepartment of Biomedical Informatics School of Basic Medical Sciences Peking University 38 Xueyuan Road Beijing 100191 China.ORCID https://orcid.org/0000-0001-5685-066X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate mapping between single-cell RNA sequencing (scRNA-seq) and low-resolution spatial transcriptomics (ST) data compensates for both limited resolution of ST data and missing spatial information of scRNA-seq. Celloc, a method developed for this purpose, incorporates a graph attention autoencoder and comprehensive loss functions to facilitate flexible single cell-to-spot mapping. This enables either the dissection of cell composition within each spot or the assignment of spatial locations for every cell in scRNA-seq data. Celloc's performance is benchmarked on simulated ST data, demonstrating superior accuracy and robustness compared to state-of-the-art methods. Evaluations on real datasets suggest that Celloc can reconstruct cellular spatial structures with various cell types across different tissues and histological regions.

Indexed as

graph attention autoencoderssingle‐cell mappingspatial transcriptomics

Identifiers

PMID40212250
PMCPMC11934999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.