ArticleAnnals of medicine and surgery (2012)2025
Assessment of safety of niraparib maintenance therapy in epithelial ovarian cancer: an updated systematic review and meta-analysis of randomized control trials.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Introduction: Patients with epithelial ovarian cancer (EOC) who are treated with niraparib maintenance therapy, experience hematological and gastrointestinal side effects. There is a scarcity of evidence on the safety of niraparib. This study aims to assess the safety profile of niraparib as a maintenance treatment for women with platinum-sensitive EOC. Methods: PubMed (Medline), EMBASE, and Google Scholar were searched for randomized controlled trials (RCTs) with people suffering from EOC. This study used Review Manager and forest plots for visual display. Random effects models were used for this meta-analysis (RRs and 95% CIs). Results: The study analyzed 2311 cases from 7/8 RCTS of niraparib-treated patients with high risks of any grade of anemia (RR, 3.51; 95% CI, 2.99 to 4.10, Conclusion: There is a need to emphasize on cautious use, hematological toxicities, and personalized dosage regimens of niraparib for improved patient compliance.
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