Evidence map›Paper›PMID 40212163›Full record

ReviewAnnals of medicine and surgery (2012)2025

Deep brain stimulation (DBS) in movement disorders management: exploring therapeutic efficacy, neurobiological mechanisms, and clinical implications.

Abbas F Abdul Hussein, Wafa Mohammad Imran, Ibrahim Serag, Abdallah Abbas, Elsayed Mohamed Hammad, Santiago Pastrana-Brandes, Sandra Thair Al-Aish, Dina Mahmoud, Ahmed Mostafa Zazo Hassan, Amr S Ghattas and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abbas F Abdul HusseinDepartment of Neurosurgery, College of Medicine, Babylon University, Babylon, Iraq.
Wafa Mohammad ImranNeurosurgery, University of Buckingham, UK.
Ibrahim SeragFaculty of Medicine Mansoura University, Mansoura, Egypt.
Abdallah AbbasFaculty of Medicine, Al-Azhar University, Damietta, Egypt.
Elsayed Mohamed HammadFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Santiago Pastrana-BrandesHarvard T. H. Chan School of Public Health, Executive and Continuing Professional Education (ECPE), Boston.
Sandra Thair Al-AishDepartment of Surgery, University of Baghdad, College of Medicine, Baghdad, Iraq.
Dina MahmoudBiomedical Sciences at the University of Science and Technology in Zewail City, Zewail City, Egypt.
Ahmed Mostafa Zazo HassanFaculty of Medicine, Cairo University, Egypt.
Amr S GhattasFaculty of Medicine, Cairo University, Egypt.
Mohamed H MegaliFaculty of Medicine, Cairo University, Egypt.
Ahmed MuthanaDepartment of Neurosurgery, University of Baghdad, Iraq.
Ali Abbas Hashim AlmusawiDepartment of Neurosurgery, Hammurabi College of Medicine, Babylon University, Babylon, Iraq.
Bipin ChaurasiaDepartment of Neurosurgery,Neurosurgery Clinic, Birgunj, Nepal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Deep brain stimulation (DBS) has emerged as a promising therapeutic approach, offering targeted neuromodulation for movement disorders refractory to medical management or stereotactic surgery. However, assessing its benefits against potential risks is essential. This meta-analysis aims to evaluate the efficacy and safety of DBS in movement disorders, shedding light on its role as an alternative therapeutic option. Methods: A comprehensive search of databases after systemic review yielded studies published in English from 2000 to the present. Data selection, screening, extraction, and risk of bias assessment were performed meticulously. Statistical analysis was conducted using RevMan 2.0, with significant heterogeneity addressed through appropriate methods. Results: Our meta-analysis included 40 studies assessing the Unified Parkinson's Disease Rating Scale Part III, revealing a significant improvement in motor symptoms (mean difference [MD]: -18.05, 95% confidence interval [CI] [-20.17, -15.93], Conclusion: DBS demonstrates efficacy in improving motor symptoms, disease severity, tremor, gait, and tic severity in movement disorders. However, further research is needed to elucidate long-term efficacy and safety outcomes.

Indexed as

deep brain stimulationmeta-analysismovement disordersparkinsonismParkinson’s diseasePD

Identifiers

PMID40212163
PMCPMC11981253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.