Evidence map›Paper›PMID 40212162›Full record

ArticleAnnals of medicine and surgery (2012)2025

The impact of gut microbiome modulation on anthropometric indices in metabolic syndrome: an umbrella review.

Maryam Sadat Aleali, Abinash Mahapatro, Gautam Maddineni, Ruchir Paladiya, Herby Jeanty, Elan Mohanty, Mohit Mirchandani, Ali Jahanshahi, Pavan Devulapally, Azin Alizadehasl and 5 more

Abstract read
In one paragraph

Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maryam Sadat AlealiGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Abinash MahapatroHi-Tech Medical College and Hospital, Rourkela, Odisha, India.
Gautam MaddineniFlorida State University, Tallahassee, Florida, USA.
Ruchir PaladiyaUniversity of Connecticut Health Center, Farmington, Connecticut, USA.
Herby JeantyThe Brooklyn Hospital Center, Brooklyn, New York, USA.
Elan MohantyGautam Maddineni, MD Mary Medical Center Apple Valley, Apple Valley, California, USA.
Mohit MirchandaniMontefiore Medical Center Wakefield Campus, Bronx, New York, USA.
Ali JahanshahiGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Pavan DevulapallySocial Determinants of Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Azin AlizadehaslFaculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Muhammad Daoud TariqMain Methodist Hospital, San Antonio, Texas, USA.
Seyedeh Fatemeh Hosseini JebelliFaculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Azam Yalameh AliabadiFaculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Seyyed Mohammad HashemiRajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran.
Ehsan Amini-SalehiGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Metabolic syndrome (MetS) is a complex disorder characterized by a cluster of metabolic risk factors. Recent research highlights the gut microbiome's role in metabolic regulation, suggesting that modulation through probiotics, prebiotics, and synbiotics may provide a novel approach to managing MetS. This umbrella review aims to integrate insights from existing meta-analyses to explore how changes in gut microbiota influence key body measurement indicators in individuals with MetS. Methods: A systematic search of PubMed, Scopus, and Web of Science databases identified meta-analyses that assessed the impact of probiotics, prebiotics, or synbiotics on anthropometric indices in MetS patients. Results: The results indicated that microbial therapy leads to a significant reduction in body mass index (BMI) (SMD: -0.22; 95% CI: -0.35 to -0.09; Conclusions: Gut microbial modulation, mainly through probiotics and synbiotics, shows promise in reducing BMI and WC in MetS patients. However, its effects on other anthropometric indices remain uncertain, warranting further high-quality research to fully understand microbial interventions' therapeutic potential.

Indexed as

anthropometric indicesgut microbiomemeta-analysismetabolic syndromeprebioticsprobioticssynbioticsumbrella review

Identifiers

PMID40212162
PMCPMC11981403

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