Evidence map›Paper›PMID 40212106›Full record

ReviewJPRAS open2025

Adipose-derived stem cells in fat grafting for facial paralysis: A review of their therapeutic modality.

Laurentia Fidella Averina Setia Santoso, Raoul Al Kassis, San Khasraw Mohammed, Lakshay Arora, Nancy Emmanuel, Gregory Nicolas, Juan Pablo Menendez

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JPRAS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laurentia Fidella Averina Setia SantosoFaculty of Medicine, Universitas Padjadjaran, Sumedang Regency and Bandung, Indonesia.
Raoul Al KassisDepartment of General Medicine, Faculty of Medical Sciences, Lebanese University, Beirut, the Lebanonese Republic.
San Khasraw MohammedSulaymaniyah General Directorate of Health, Shar Hospital, Sulaymaniyah, Kurdistan Region 46001, Iraq.
Lakshay AroraUniversity of Perpetual Help Jonelta Foundation School of Medicine, Las Piñas, Philippines.
Nancy EmmanuelDepartment of Dermatology, Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.
Gregory NicolasDepartment of Plastic and Reconstructive Surgery, Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.
Juan Pablo MenendezDepartment of Plastic and Reconstructive Surgery, Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Facial paralysis, characterized by the complete loss of voluntary muscle control in the face, significantly affects individuals' daily lives. Recently, stem cell therapy has gained attention as a potential treatment for various medical conditions due to its capacity for self-renewal and differentiation into specialized cell types. Adipose-derived stem cells (ADSCs), obtained from the stromal-vascular fraction, consist of mesenchymal stem cells (MSCs), smooth muscle cells, endothelial cells, pericytes, lymphocytes, and tissue macrophages. Both differentiated and undifferentiated MSCs support axonal regeneration, enhance motor function, and promote growth factor release. ADSCs have been shown to improve regenerative outcomes, including better axonal development, increased myelinated fiber count, greater myelin thickness, and enhanced target reinnervation. These cells can differentiate into various lineages, particularly Schwann-like cells that facilitate axon regeneration. Additionally, ADSCs play a role in healing peripheral nerves by releasing neurotrophic and angiogenic factors. While the results are not as effective as nerve autografts, ADSCs offer an alternative option for reconstructing facial nerve paralysis.

Indexed as

Adipose-derived stem cellsFacial palsyFacial paralysisFat graftingStem cells

Identifiers

PMID40212106
PMCPMC11984942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.