ArticleJournal of oral biology and craniofacial research
Effective treatment of oral microbial infections and biofilm using flavonoid rutin - An
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Seasonal Variation of a New Brazilian Greenish-Brown Propolis Type: Chemical Composition and Antioxidant, Antimicrobial, and Antileishmanial Activities.Molecules (Basel, Switzerland) · 2026Article
- Inhibitory effects of Quercetagetin on the growth, biofilm formation, and virulence factors of bovine mastitis-associatedFrontiers in microbiology · 2026Article
- Diospyros kaki L. (persimmon) as a potential antibiofilm agent against Acinetobacter pittii, Acinetobacter baumannii, and Pseudomonas aeruginosa isolated from diabetic foot patients.World journal of microbiology & biotechnology · 2025Article
- Phytochemical Profiling ofMolecules (Basel, Switzerland) · 2025Article
- Evaluation of Surface Roughness and Microbial Adhesion of Primary Esthetic Crowns: AnInternational journal of clinical pediatric dentistry · 2025Article
- Possible applicability of flavonoid hesperetin for the treatment of dental biofilm-formingJournal of oral biology and craniofacial researchArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral microbial infections and biofilm-associated conditions, such as dental caries, gingivitis, and periodontitis, remain major challenges in oral healthcare. Biofilms provide resistance to conventional antimicrobial treatments, necessitating innovative solutions. This study investigates rutin, a flavonoid glycoside, for its antimicrobial and antibiofilm properties against key oral pathogens. Aim: To evaluate the antibacterial and antibiofilm efficacy of rutin against oral pathogens, including Methodology: Oral pathogens were isolated from clinical samples and identified using the VITEK®2 Compact System. Antimicrobial activity of five flavonoids was screened using the well diffusion method, with rutin demonstrating the highest efficacy. Minimum inhibitory concentration (MIC) and antibiofilm activity were assessed using broth microdilution and crystal violet staining, respectively. Confocal Laser Scanning Microscopy analyzed live/dead cells in treated biofilms. Hemocompatibility was evaluated via a hemolysis assay. Results: Rutin exhibited significant antimicrobial activity with zone of inhibition as 19 mm ( Conclusion: Rutin demonstrates potent antimicrobial and antibiofilm efficacy with excellent safety, suggesting its potential as an alternative therapy for biofilm-associated oral infections. Further in vivo studies are warranted to validate these findings.
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Registered trials
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