ArticleFrontiers in artificial intelligence2025
SciLinker: a large-scale text mining framework for mapping associations among biological entities.
Article in Frontiers in artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Introduction: The biomedical literature is the go-to source of information regarding relationships between biological entities, including genes, diseases, cell types, and drugs, but the rapid pace of publication makes an exhaustive manual exploration impossible. In order to efficiently explore an up-to-date repository of millions of abstracts, we constructed an efficient and modular natural language processing pipeline and applied it to the entire PubMed abstract corpora. Methods: We developed SciLinker using open-source libraries and pre-trained named entity recognition models to identify human genes, diseases, cell types and drugs, normalizing these biological entities to the Unified Medical Language System (UMLS). We implemented a scoring schema to quantify the statistical significance of entity co-occurrences and applied a fine-tuned PubMedBERT model for gene-disease relationship extraction. Results: We identified and analyzed over 30 million association sentences, including more than 11 million gene-disease co-occurrence sentences, revealing more than 1.25 million unique gene-disease associations. We demonstrate SciLinker's ability to extract specific gene-disease relationships using osteoporosis as a case study. We show how such an analysis benefits target identification as clinically validated targets are enriched in SciLinker-derived disease-associated genes. Moreover, this co-occurrence data can be used to construct disease-specific networks, providing insights into significant relationships among biological entities from scientific literature. Conclusion: SciLinker represents a novel text mining approach that extracts and quantifies associations between biomedical entities through co-occurrence analysis and relationship extraction from PubMed abstracts. Its modular design enables expansion to additional entities and text corpora, making it a versatile tool for transforming unstructured biomedical data into actionable insights for drug discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.