Evidence map›Paper›PMID 40212074›Full record

ArticleSmall science2024

Quantitative Single-Cell Comparison of Sensitization to Radiation and a Radiomimetic Drug for Diverse Gold Nanoparticle Coatings.

Douglas Howard, Tyron Turnbull, Puthenparampil Wilson, David John Paterson, Valentina Milanova, Benjamin Thierry, Ivan Kempson

Abstract read
In one paragraph

Article in Small science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Douglas HowardFuture Industries Institute University of South Australia Mawson Lakes South Australia 5095 Australia.
Tyron TurnbullFuture Industries Institute University of South Australia Mawson Lakes South Australia 5095 Australia.
Puthenparampil WilsonUniSA STEM University of South Australia Mawson Lakes South Australia 5095 Australia.
David John PatersonAustralian Synchrotron ANSTO 800 Blackburn Road Clayton Victoria 3168 Australia.
Valentina MilanovaFuture Industries Institute University of South Australia Mawson Lakes South Australia 5095 Australia.
Benjamin ThierryFuture Industries Institute University of South Australia Mawson Lakes South Australia 5095 Australia.
Ivan KempsonFuture Industries Institute University of South Australia Mawson Lakes South Australia 5095 Australia.ORCID https://orcid.org/0000-0002-3886-9516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-based nanoparticles (NPs) have entered clinical use for enhancing radiotherapy, but the underlying mechanisms remain ambiguous. Herein, single-cell analysis of two cell lines in response to megavolt irradiation and a radiomimetic drug, neocarzinostatin (NCS) after coculture with gold NPs with different surface coatings, polyethylene glycol (AuPEG), PEG, and transferrin (AuT) or silica (AuSiO

Indexed as

cancerDNA damagedouble‐strand breaksnanomedicinephysical chemistryradiotherapyγH2AX

Identifiers

PMID40212074
PMCPMC11935229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.