ArticleFrontiers in pediatrics2025
Effect of moderate hyperbilirubinemia on an infant's brain: a quantitative susceptibility mapping and
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The effects of moderate neonatal hyperbilirubinemia (NHB) remain unknown. The aim of this work was to investigate whether moderate NHB has an impact on an infant's brain and explore the relationship between brain magnetic susceptibility, brain metabolites, and biochemical tests in moderate NHB using quantitative susceptibility mapping (QSM) and magnetic resonance spectroscopy (MRS). Materials and methods: In total, 28 term babies with moderate levels of blood bilirubin were enrolled in the NHB group, and 16 term infants were enrolled in the control group. All the patients underwent biochemical tests, 1H-MRS, and QSM examinations. Biochemical test results [e.g., direct bilirubin (DBiL)], metabolite ratios [e.g., glycerophosphocholine (GPC)], and susceptibility values were collected. The Mann-Whitney Results: The Mann-Whitney Conclusion: This study demonstrated that moderate hyperbilirubinemia could induce metabolic and susceptibility changes in an infant's brain (e.g., decreased susceptibility values and metabolite values) and these changes have a correlation with biochemical test results.
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