ArticleSmall science2023
Ultraminiaturized Microfluidic Electrochemical Surface-Enhanced Raman Scattering Chip for Analysis of Neurotransmitters Fabricated by Ship-in-a-Bottle Integration.
Article in Small science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Next-Generation SERS Probes: Engineering Hotspots, Intelligent Molecular Targeting, and AI-Driven Spectral Analysis for Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry.Sensors (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrochemical surface-enhanced Raman scattering (EC-SERS) is a promising technique for the diagnosis of trace amounts of neurotransmitters, because it can elucidate neurotransmitters' behavior on electrodes to deduce their functions in the human body. However, the current EC-SERS devices need several tens of milliliters of analyte solution to collect enough signal for analysis. Miniaturization of EC-SERS devices is crucial for the early diagnosis of disease and point-of-care testing. Herein, a new type of EC-SERS sensor based on 3D microfluidic chips for the analysis of neurotransmitters in ultrasmall volumes is proposed. The microfluidic EC-SERS chip is fabricated by a ship-in-a-bottle technique based on hybrid laser processing. The working electrode is modified using silver/zinc oxide materials, enabling the formation of a unique "candy apple" structure. To assess the fabricated microfluidic EC-SERS chips, ascorbic acid is analyzed using the ingenious microfluidic EC-SERS chips to elucidate its redox reaction by EC-SERS spectroscopy. Significantly, a sub-10 μL volume of analyte solution is sufficient for EC-SERS analysis, which is several orders smaller in volume than the requirements of current EC-SERS devices. The unprecedented microfluidic EC-SERS chips fabricated by the ship-in-a-bottle integration technique can be used in portable and smart analyzers for next-generation biomedicines and catalysts.
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Registered trials
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