ArticleCurrent medicinal chemistry2025
Assessment of the Toxicity of Free and PLGA-Encapsulated Phospholipase A2 CB: An
Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- New Insights from Toxinology in Mammalian Reproduction: A Systematic Review.Mini reviews in medicinal chemistry · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundThe use of bioactive molecules isolated from rattlesnake venom and other poisons has been ongoing for years. Among these bioactive compounds present in snake venom, crotoxin (CTX) stands out as a β-heterodimeric neurotoxin isolated from the venom of
methodsThis study aimed to evaluate the in vitro toxic action of CTX and its phospholipase A2 CB (PLA2CB) component, both free and encapsulated in polymeric nanoparticles. The inhibitory concentration value of 50% tumor growth (IC
resultsThe cell death mechanism triggered by CTX and PLA2CB exhibited characteristics associated with the necrotic process. However, polymeric nanoparticles containing PLA2CB (NP-PLA2CB) demonstrated apoptosis-like cell death processes in flow cytometry. PLGA polymeric nanoparticles containing PLA2CB were synthesized using microfluidics, resulting in NP-PLA2CB with a diameter of 91 ± 2.9 nm and a zeta potential of -21.8 ± 3.2 mV. The encapsulation efficiency of PLA2CB was approximately 70% (protein content).
conclusionIt was concluded that using the phospholipase component of the toxin in a polymeric-controlled delivery and targeted system may be an alternative solution to the issues in advancing this bioactive molecule in clinical-oncological studies. However, further studies are still being conducted for targeted treatment involving this nanotechnological approach.
Indexed as
Identifiers
40211991What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.