ArticleJournal of cosmetic dermatology2025
Biodegradability and Efficacy of Porous Polycaprolactone Microsphere Dermal Filler for Fine Lines.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Understanding Polycaprolactone Degradation: Molecular Mechanisms and Implications for Biomedical Device Design.Materials (Basel, Switzerland) · 2026Review
- Regenerative Functional Microspheres for Aesthetic Medicine: Mechanism, Materials, Fabrication, and Clinical Applications.Advanced healthcare materials · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong various filler products designed to improve facial wrinkles, those using biodegradable polymer microspheres have gained attention. Recently, a filler composed of porous polycaprolactone (PCL) microspheres was introduced.
aimThis study aimed to evaluate and understand the mechanism of PCL biodegradability, safety, and efficacy in reducing wrinkles.
methodsTo examine the degradation characteristics in vitro, the filler product was incubated in phosphate-buffered saline (pH 7.4) at 37°C, 45°C, and 55°C. Samples from 1 to 104 weeks were obtained to determine changes in the morphology and molecular weight of the porous PCL microspheres. In addition, the product was administered to rabbits to evaluate its in vivo degradability. Treated tissues were sampled at 6, 12, 18, 24, and 30 months to examine the biodegradability of the microspheres. Tissue safety and collagen fiber production were evaluated at the same time points. The anti-wrinkle effect was evaluated using PRIMOS to measure changes in skin surface roughness in a photoaging mouse model.
resultsIn vitro testing revealed that the porous PCL microspheres degraded progressively over time, forming cracks on the surface and showing a decrease in molecular weight. In vivo studies demonstrated that the product degraded safely in tissues and induced collagen formation. Furthermore, skin roughness evaluation using a photoaging mouse model confirmed its anti-wrinkle effects.
conclusionThe filler product based on porous PCL microspheres was found to be safely biodegraded in vivo and effectively improved wrinkles.
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Registered trials
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