SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2025
Cryolipolysis and associated health outcomes, adverse events, and satisfaction: A systematic review and meta-analysis.
Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Synergistic Mechanisms and Clinical Efficacy of Combined Shockwave and Ultrasound Therapy for Localized Adiposity: A Systematic Review and Meta-Analysis of 31 Studies.Aesthetic plastic surgery · 2026Pooled it
- Cryolipolysis and associated health outcomes, adverse events, and satisfaction: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- New Updates in Adipocytes and Adipose Tissue: 2nd Edition.Life (Basel, Switzerland) · 2026Article
- A Case Series on Minimally Invasive Upper Arm Contouring: Efficacy of Combined Renuvion Helium Plasma and Icoone Multi-Micro Alveolar Stimulation for Fat Reduction.Clinical case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCryolipolysis is a nonsurgical adiposity reduction treatment that is increasing in popularity globally. The aim of this paper was to carry out a systematic review with meta-analysis on cryolipolysis and associated health outcomes, adverse events (AE) and patient satisfaction.
methodsMajor databases were searched from inception until April 4, 2024. Meta-analysis was performed using random-effect models to calculate the pooled effects size and 95% confidence interval (CI) of each finding. The systematic review protocol was registered on PROSPERO, CRD-42024548077.
resultsA total of 30 studies were included, including 3158 participants. The result of meta-analyses showed reduced body mass index (mean differences [MD] = -1.80, 95% confidence interval [CI] -2.98, -0.62, p = 0.0003), waist-to-hip ratio (MD = -0.09, 95% CI -0.16, -0.02, p = 0.001), mean abdominal circumference (cm) (MD = -3.56, 95% CI -4.98, -2.15, p = 0.000001), and mean suprailiac fat thickness (FT) (mm) (MD = -5.22, 95% CI -9.03, -1.42, p = 0.0007), 12 weeks after cryolipolysis as compared with baseline values. The satisfaction rate was 80.4% and the AE of cryolipolysis was 49.5% for numbness, 44.5% for erythema, 30.5% for edema, 28.8% for pain, 25.4% for sensitivity, 15.2% for tingling, and 2% for hyperpigmentation.
conclusionIn the present study, it was found that cryolipolysis was associated with a reduction in the number of adiposity parameters at 3 months follow-up. A relatively high level of minor AEs was reported; however, patient satisfaction was high suggesting that the treatment is well tolerated.
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