ArticleClinical and experimental pediatrics2025
Role of miRNA-146a and miRNA-125b in Helicobacter pylori.
Article in Clinical and experimental pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Fecal miR-146a as a Non-Invasive Biomarker forLife (Basel, Switzerland) · 2026Article
- MicroRNAs as Orchestrators of Immune Responses to Bacterial Infection.Microorganisms · 2026Review
- Inhibition of microRNA-155 regulates gastric mucosal barrier repair and inflammation by targeting SOCS1 for the treatment of acute gastritis.Scientific reports · 2025Article
- Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer.BMC gastroenterology · 2025Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori infection is a common gastrointestinal pathogen associated with gastritis and peptic ulcers. The early detection of H. pylori-related gastritis is crucial to its effective management, especially in pediatric patients with dyspepsia. PURPOSE: This study aimed to assess the expression of miRNA-146a and miRNA-125b as potential indicators of H. pylori-associated gastritis in children.
methodsThis cross-sectional study included 70 H. pylori-positive children and 50 H. pylori-negative controls aged ≤18 years with recurrent abdominal pain who underwent upper gastrointestinal endoscopy. The miRNA-146a and miRNA-125b expression levels in gastric biopsies were determined using quantitative reverse transcriptase-polymerase chain reaction.
resultsH. pylori-positive children had significantly higher levels of miRNA-146a than H. pylori-negative children across all endoscopic findings (range, 2.2-2.7 vs. 1.07-1.2; P<0.001) and histologic grades of gastritis (range, 2.0-2.4 vs. 1.2-1.3; P<0.001). Conversely, the H. pylori-positive group showed consistently lower miRNA-125b levels across all parameters (range, 0.3-0.8 vs. 0.4-0.9; P<0.001). Both miRNAs differentiated H. pylori status with an area under the curve of >0.95.
conclusionThe altered expression of miRNA-146a and miRNA-125b in gastric biopsies of H. pylori-positive children suggests their potential role as molecular markers of H. pylori-associated gastritis.
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