Evidence map›Paper›PMID 40211826›Full record

ArticleActa biochimica et biophysica Sinica2025

Reduced expression of the PER2 protein contributes to β

Pengjia Li, Jiayan Feng, Jiao Guo, Jin Xue, Yang Li, Shiyuan Wen, Xiaohui Wang, Huirong Liu, Li Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pengjia LiResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Jiayan FengResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Jiao GuoResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Jin XueResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Yang LiResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Shiyuan WenResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Xiaohui WangResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Huirong LiuSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Li WangResearch Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure may be linked to fluctuations in the rhythm of autophagy in cardiomyocytes throughout the day. Circadian rhythms depend on the regulation of core biological clock proteins, with PER2 playing a crucial role. Our previous research confirmed that the presence of β

Indexed as

AutophagyMyocytes, CardiacPeriod Circadian ProteinsReceptors, Adrenergic, beta-1AnimalsMechanistic Target of Rapamycin Complex 1Microtubule-Associated ProteinsRatsTOR Serine-Threonine KinasesMechanistic Target of Rapamycin Complex 1Microtubule-Associated ProteinsPeriod Circadian ProteinsReceptors, Adrenergic, beta-1TOR Serine-Threonine Kinasesautophagy rhythmbiological clockmTORC1PER2β-AA

Identifiers

PMID40211826
PMCPMC12536457

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.