Evidence map›Paper›PMID 40211766›Full record

ArticleObesity (Silver Spring, Md.)2025

Age, race and ethnicity, and sex of participants in clinical trials related to obesity.

Leah M Schumacher, Joseph Chibueze, Francesca M Knudsen, Astha Rajpal, Siddhartha Kalala, Ksenia Power, Julie K Silver, Helen Burton-Murray

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leah M SchumacherDepartment of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1557-4659
Joseph ChibuezeLewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Francesca M KnudsenDepartment of Psychology, College of Education and Human Services, Utah State University, Logan, Utah, USA.
Astha RajpalDepartment of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, Pennsylvania, USA.
Siddhartha KalalaBrown University, Providence, Rhode Island, USA.
Ksenia PowerDepartment of Health and Rehabilitation Sciences, College of Public Health, Temple University, Philadelphia, Pennsylvania, USA.
Julie K SilverDepartment of Orthopedics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Helen Burton-MurrayHarvard Medical School, Boston, Massachusetts, USA.

Funding

A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional DyspepsiaK23DK131334 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURTON MURRAY, HELEN · 2021 to 2025
$1.1M
NHLBI NIH HHS L30 HL154167NIDDK NIH HHS K23 DK131334
6 · The paper itself

Abstract

objectiveFederal policies mandate the inclusion of historically marginalized groups in clinical trials and sociodemographic reporting on ClinicalTrials.gov. This study used ClinicalTrials.gov to comprehensively assess sociodemographic reporting and representation in obesity-related trials.

methodsAge, race and ethnicity, and sex data were extracted for interventional studies completed in the United States with results from January 1, 2012, to October 13, 2023. We assessed the frequency of sociodemographic reporting and sample representation (equitable, over, or under), as determined by comparing the percentage of trial participants with each characteristic to US Census data and obesity-specific estimates.

resultsThe search yielded 847 study records, 449 of which were eligible. Most studies (>99%) reported sex; older age (33%), race (75%), and ethnicity (57%) were less commonly reported, although race and ethnicity reporting increased over time (p values <0.001). The following three patterns emerged for representation: 1) individuals identifying as Black/African American were slightly overrepresented relative to the comparators; 2) representation of older adults and other racial and ethnic identities was more mixed and differed by trial type; and 3) female participants were overrepresented.

conclusionsProgress has been made in reporting and representation, although gaps remain. Given obesity-related health disparities and reasons for inclusion beyond population-based representation (e.g., subgroup analyses), continued efforts are needed to enhance reporting and representation.

Indexed as

Clinical Trials as TopicEthnicityObesityRacial GroupsAdultAgedAge FactorsBlack or African AmericanFemaleHumansMaleMiddle AgedPatient SelectionSex FactorsUnited StatesYoung Adult

Identifiers

PMID40211766
PMCPMC12221220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.