ArticleMolecular medicine reports2025
Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis.
Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Article
- Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells.Frontiers in pharmacology · 2026Article
- Article
- Pristimerin Dampens Acetaminophen-Induced Hepatotoxicity; The Role of NF-κB/iNOS/COX-II/Cytokines, PI3K/AKT, and BAX/BCL-2/Caspase-3 Signaling Pathways.Pharmaceutics · 2025Article
- Cuproptosis: a novel therapeutic mechanism in lung cancer.Cancer cell international · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcerative colitis (UC) is a non‑specific inflammatory bowel disease characterized by inflammation of the colonic and rectal mucosa and submucosa and has a globally increasing incidence. A compromised intestinal epithelial barrier function has been established as the primary etiological factor in UC, with necroptosis of intestinal epithelial cells exacerbating barrier disruption. Consequently, the inhibition of necroptosis in these cells has the potential to ameliorate colitis severity and preserve intestinal integrity, thereby offering a promising therapeutic approach for UC management. Pristimerin, a naturally occurring pentacyclic triterpenoid derived from
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Registered trials
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