ArticleJournal of cachexia, sarcopenia and muscle2025
Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- NSAIDs trigger drug-specific response to exercise: a multi-omics systems biology analysis of a randomized crossover trial.Skeletal muscle · 2026Trial
- The effect of nimesulide on skeletal muscle hypertrophy and load progression after 8 weeks of resistance training in wistar rats.Journal of muscle research and cell motility · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-steroidal anti-inflammatory drugs (NSAIDs) may influence musculoskeletal health. The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6 weeks of aerobic exercise.
methodsNine-week-old male Wistar rats (n = 80) were randomized to either exercise (EX) or no-exercise control (CON) conditions and treated with naproxen, ibuprofen (IBU), flurbiprofen (FLU) or placebo (PLA). For exercise, rats ran 5 days per week for 6 weeks at a 5% incline on a motorized treadmill for 30 min. Three-point bending (3 PB) and microcomputed tomography (microCT) were measured in the femur. Anabolic muscle signalling pathways were measured in the quadriceps. Muscle fibre cross-sectional area (CSA) and fibre type were measured in the soleus. Data were analysed using a two-way ANOVA for treatment by condition and is visualized as mean ± standard deviation.
resultsFor 3 PB, there was an exercise effect for ultimate bending energy, postyield energy, toughness, postyield toughness, postyield displacement, ultimate strain and postyield strain (all, p < 0.05). There was a treatment by condition effect for Young's Modulus, where placebo exercise was less than placebo control (PLA EX: 3256.44 ± 463.41 MPa, PLA CON: 4849.94 ± 836.70 MPa, p < 0.05). For microCT, there was a treatment by condition effect for trabecular thickness (p = 0.047) and the IBU EX group increased thickness compared with the IBU CON group (IBU EX: 0.133 ± 0.011 mm, IBU CON: 0.121 ± 0.007 mm, p = 0.027). In the quadriceps, for myosin heavy chain abundance, there was a treatment by condition effect (p = 0.046) and ibuprofen exercise was lower than ibuprofen control (IBU EX: 0.636 ± 0.513 AU, IBU CON: 1.81 ± 1.012 AU, p = 0.016). There was no treatment by condition effect for phosphorylation of the AKT, AMPK or ERK pathways (all, p > 0.05). In the soleus, there was no treatment by condition effect for fibre type percentage or muscle CSA (p > 0.05).
conclusionsNSAIDs did not have a strong negative or positive effect on musculoskeletal adaptations to 6 weeks of treadmill running in young healthy male rodents.
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