Evidence map›Paper›PMID 40211433›Full record

ArticleJournal of translational medicine2025

Altered immune signatures in breast cancer lymph nodes with metastases revealed by spatial proteome analyses.

Oscar Briem, Balázs Tahin, Asger Meldgaard Frank, Lina Olsson, Anna Sandström Gerdtsson, Eva Källberg, Karin Leandersson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oscar BriemCancer Immunology, Department for Translational Medicine, Clinical Research Center, Lund University, Jan Waldenströms gata 35, Malmö, SE-214 28, Sweden.
Balázs TahinDivision of Clinical Pathology, Department of Clinical Sciences, Lund University, Malmö, 214 28, Sweden.
Asger Meldgaard FrankDivision of Immunotechnology, Faculty of Engineering, Lund University, Malmö, 211 00, Sweden.
Lina OlssonDivision of Immunotechnology, Faculty of Engineering, Lund University, Malmö, 211 00, Sweden.
Anna Sandström GerdtssonDivision of Immunotechnology, Faculty of Engineering, Lund University, Malmö, 211 00, Sweden.
Eva KällbergCancer Immunology, Department for Translational Medicine, Clinical Research Center, Lund University, Jan Waldenströms gata 35, Malmö, SE-214 28, Sweden.
Karin LeanderssonCancer Immunology, Department for Translational Medicine, Clinical Research Center, Lund University, Jan Waldenströms gata 35, Malmö, SE-214 28, Sweden. Karin.Leandersson@med.lu.se.ORCID 0000-0001-8254-3137

Funding

Allmänna Sjukhusets i Malmö Stiftelse för Bekämpande av Cancer Allmänna Sjukhusets i Malmö Stiftelse för Bekämpande av CancerCancerfonden 21 1392 Pj 01 HGyllenstiernska Krapperupsstiftelsen Gyllenstiernska KrapperupsstiftelsenKungliga Fysiografiska Sällskapet i Lund Kungliga Fysiografiska Sällskapet i LundRegional grants from the Swedish state under the agreement between the Swedish government and the county councils the ALF-agreement Regional grants from the Swedish state under the agreement between the Swedish government and the county councils the ALF-agreementVetenskapsrådet 2020-01842
6 · The paper itself

Abstract

backgroundMetastasis to lymph nodes is strongly associated with reduced survival in breast cancer patients. To increase the understanding on how lymph node metastasis impairs the local immune response in affected lymph nodes, we here studied spatial proteomic changes of critical lymph node immune populations in uninvolved lymph nodes (UnLN) and paired lymph nodes with metastases (LNM) from five breast cancer patients.

methodsThe proteome was analyzed for cortical lymphocyte compartments, subcapsular sinus (SCS) and medullary sinus (MS) CD169

resultsOur results identified a stable proteome of SCS CD169

conclusionsThe findings from our study support the notion that metastasis to lymph nodes in breast cancer patients modifies local immune responses. These changes may contribute to explain unsuccessful therapeutic responses, and thereby worsened prognosis, for breast cancer patients with LNM.

Indexed as

Breast NeoplasmsLymphatic MetastasisLymph NodesProteomeProteomicsFemaleHumansMacrophagesMiddle AgedSialic Acid Binding Ig-like Lectin 1ProteomeSialic Acid Binding Ig-like Lectin 1B-cell folliclesBreast cancerCD169+ macrophagesGerminal centersInterfollicular T-cellsLymph node metastasis

Identifiers

PMID40211433
PMCPMC11987258

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.