Saikosaponin D inhibits the inflammatory response of secretory otitis media through FTO-mediated N

Minjing Yin, Xiuli Han

Abstract read

In one paragraph

Article in BMC pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Minjing YinDepartment of Otolaryngology, The Guang'anmen Hospital, of the China Academy of Chinese Medical Sciences in Jinan, Jinan City Traditional Chinese Medicine Hospital, Jinan, 250000, China.

Xiuli HanDepartment of Otolaryngology, First Clinical School of Shandong, University of Traditional Chinese Medicine, No.42 Wenhua West Road, Jinan, Shandong, 250011, China. drxiulihan@outlook.com.

Funding

Project of Shandong Provincial Administration of Traditional Chinese Medicine 2020-03

6 · The paper itself

Abstract

Secretory Otitis Media (SOM) is a non-suppurative inflammatory disease of the middle ear. Saikosaponin D (SSD), a compound with significant anti-inflammatory and immunomodulatory properties, was investigated for its preventive effects and underlying mechanisms against SOM. A rat model of SOM was established through intraperitoneal ovalbumin injection. Middle ear lavage fluid (MELF) and tissue samples were collected for comprehensive analysis, including bacterial load quantification, neutrophil enumeration, and inflammatory factor assessment. HEK293T cells were utilized for mechanistic validation. Our findings demonstrated that SSD preventive treatment significantly reduced colony-forming units (CFUs) in SOM-induced rats, attenuated middle ear mucosal thickening, and suppressed pro-inflammatory cytokine levels (TNF-α, IL-6, and INF-γ). Mechanistically, SSD treatment counteracted SOM-induced m

Indexed as

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnti-Inflammatory AgentsOleanolic AcidOtitis MediaSaponinsToll-Like Receptor 4AnimalsCytokinesHEK293 CellsHumansMaleRatsRats, Sprague-DawleyRNA, MessengerAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnti-Inflammatory AgentsCytokinesN-methyladenosineOleanolic AcidRNA, Messengersaikosaponin DSaponinsTLR4 protein, humanTlr4 protein, ratToll-Like Receptor 4FTON6-methyladenosineNeutrophilSaikosaponin DSecretory otitis mediaTLR4

Identifiers

PMID40211323

DOI10.1186/s40360-025-00910-6

PMCPMC11987459

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.