ArticleBMC infectious diseases2025
Demographic and regional trends of sepsis mortality in the United States, 1999-2022.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A bibliometric and visual analysis of research trends and hotspots in sepsis-related immunosuppression (2005-2025).Frontiers in pharmacology · 2026Pooled it
- Nationwide analysis of adult nongonococcal septic knee arthritis hospitalizations from 2016 to 2022.Proceedings (Baylor University. Medical Center) · 2026Article
- Trends in mortality involving coexisting lung cancer and sepsis in the United States: a CDC WONDER analysis, 1999-2024.BMC pulmonary medicine · 2026Article
- Perspective on Lessons Not Learned: From Coley's Toxins to Microbial Drug Delivery, Guidance for Institutional Review Boards (IRBs).International journal of molecular sciences · 2026Review
- Trends in mortality from cancer and sepsis in the United States, 1999 to 2023: An analysis of CDC WONDER data.Medicine · 2026Article
- Trends and disparities in urinary tract infections-related mortality in the United States from 1999 to 2023: Insights from CDC WONDER.Medicine · 2026Article
- Clinical characteristics and prognostic analysis of sepsis in immunocompromised and non-immunocompromised patients: a prospective cohort study in the emergency department.BMC infectious diseases · 2026Article
- The economic value of preventing projected sepsis-related deaths among adults in 79 countries, 2000-2023, with projections to 2050: a modelling study.Critical care (London, England) · 2026Article
- Pathway-level profiling of the sepsis proteome reveals immune and transcriptional dysregulation.Molecular medicine (Cambridge, Mass.) · 2026Article
- Dysregulation of Neutrophil-Endothelial Communication in Sepsis: Mechanisms and Therapeutic Perspectives.Cells · 2026Review
- Trends in mortality among patients with malignant neoplasm of kidney in the United States, 1999-2023: a retrospective study.BMC cancer · 2026Article
- Temporal patterns in diabetes and sepsis mortality in older Americans: a population-based analysis.BMC geriatrics · 2026Article
- Mortality trends of malignant neoplasm of kidney among 5-85+ year-olds in the United States: a retrospective analysis.Frontiers in oncology · 2026Article
- Trends, disparities, and forecasts of peripheral artery disease- and sepsis-associated mortality in the United States, 1999-2023.Frontiers in medicine · 2026Article
- Association of blood urea nitrogen to albumin ratio with short-term mortality in critically ill patients with urosepsis.Frontiers in medicine · 2026Article
- Association between lactate dehydrogenase-to-albumin ratio and short-term mortality in critically ill patients with urosepsis: evidence from dual retrospective cohorts.Frontiers in cellular and infection microbiology · 2026Article
- Demographic and regional trends in pneumonia and sepsis related mortality in the U.S., 1999-2020: a CDC wonder database analysis.Frontiers in public health · 2026Article
- Nationwide trends and disparities in deaths following cardiogenic shock and sepsis in the United States (1999-2023): insights from the CDC WONDER database.BMC cardiovascular disorders · 2025Article
- Trends and Disparities in Mortality due to Diabetes Mellitus and Sepsis in the US Adults: 1999-2023.Endocrinology, diabetes & metabolism · 2025Article
- Declining Myocarditis Mortality in the United States and the Impact of the COVID-19 Pandemic.Journal of clinical medicine · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is one of the leading causes of death in the United States. We aimed to explore long term demographic and geographical trends of sepsis-related mortality in the United States from 1999 to 2022. The Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) national database was utilized to analyze differences in mortality associated with sepsis. Age-adjusted mortality rates (AAMR) were calculated, and Joinpoint Regression Program was used to determine trends for mortality. The results demonstrated that 4,177,071 deaths occurred during the study and that mortality increased for most demographic and geographic groups. Sepsis associated mortality did not witness any dramatic change from an AAMR of 77.51 in 1999 to 76.1 in 2019 but saw an increase of 30.22% from 2019 to 2021 which was primarily driven by associated COVID- 19 infections. Demographic and geographical disparities persisted with Men, NH African American and NH American Indians and Alaskan Natives, census region south having worse AAMRs. COVID- 19 contributed to around 1/6 th of sepsis associated deaths in US between 2020 and 2022 and accounted for most of the excess sepsis associated mortality during the pandemic.
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