Trial reportBMC anesthesiology2025
The effects of ciprofol on haemodynamics under general anaesthesia during thoracoscopic surgery: a randomised, double-blind, controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ciprofol versus propofol and the risk of hemodynamic adverse events: a meta-analysis with trial sequential analysis of randomized controlled trials.BMC anesthesiology · 2026Pooled it
- A comparison of ciprofol-nalbuphine versus propofol-nalbuphine on safety and efficacy during gastrointestinal endoscopy: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Dexamethasone Alone versus Combined with Droperidol for Preventing Postoperative Nausea and Vomiting in Gynecological Day Surgery Under Ciprofol-Alfentanil Anesthesia: A Randomized Double-Blind Controlled Trial.Drug design, development and therapy · 2026Trial
- Efficacy and Safety of Ciprofol Alone versus Ciprofol with Fentanyl for Upper Gastrointestinal Endoscopy: A Randomized, Double-Blind, Controlled Trial.Drug design, development and therapy · 2025Trial
- Propofol attenuates angiogenesis by activating endoplasmic reticulum stress to suppress TFAP2C-driven VEGFA transcription.Apoptosis : an international journal on programmed cell death · 2026Article
- Intraoperative bradycardia leading to cardiac arrest during anterior lumbar interbody fusion (ALIF) in a morbidly obese patient-a rare complication and management strategy: a case report.Journal of spine surgery (Hong Kong) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPropofol, a widely administered sedative, is associated with potential hemodynamic instability during anaesthesia. Ciprofol introduces a cyclopropyl group to the chemical structure of propofol, forming an R-shaped hand structure and is characterised by rapid induction, rapid recovery, good controllability and a high degree of clinical safety.
methodsThis prospective randomised, double-blind, controlled clinical trial aimed to assess the effects of ciprofol on haemodynamics and its safety and efficacy under general anaesthesia during thoracoscopic surgery. A total of 60 patients undergoing thoracoscopic surgery at First Affiliated Hospital of Guangxi Medical University between March 2023 and June 2023 were enrolled and 1:1 randomly assigned to receive anaesthesia with ciprofol or propofol. The primary outcomes were the incidences of cardiovascular events including hypertension, hypotension, bradycardia and tachycardia, the fluctuations in haemodynamic parameters. The secondary outcomes were injection pain, the bispectral index (BIS), the time of loss of consciousness and the time of disappearance of the eyelash reflex. For baseline characteristics, continuous variables were compared using Student's t-tests or Wilcoxon rank-sum tests, while categorical variables were analysed using the Chi-square test. For fluctuations in haemodynamic parameters, repeated measures analysis of variance (ANOVA) was performed.
resultsThe Chi-square tests revealed no difference in the incidence of cardiovascular events (hypertension, hypotension, bradycardia and tachycardia) between ciprofol group and propofol group during both anaesthesia induction and maintenance. The ANOVA test showed that the decrease of mean arterial pressure (MAP) at T1 was gentler in the ciprofol group compared to the propofol group (p = 0.02). The difference between the heart rate at T5 and baseline (▲HR) in the ciprofol group was significantly lower than in the propofol group (p = 0.01). The ciprofol group had a lower incidence of injection pain in comparison with the propofol group (10.0% versus 23.3%, p = 0.028). The time of disappearance of the eyelash reflex was less in the ciprofol group than in the propofol group (p = 0.004).
conclusionsCiprofol is a safe and effective anaesthetic that may be used as a substitute for propofol in the induction and maintenance of anaesthesia in thoracoscopic surgery.
trial registrationThis study was registered in the Chinese Clinical Trial Registry (ChiCTR2300069650) on March 22, 2023.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.