Evidence map›Paper›PMID 40211066›Full record

ArticleBone marrow transplantation2025

Impact of center volume on outcomes in allogeneic hematopoietic cell transplantation for children.

Motohiro Kato, Hideki Nakashone, Keitaro Matsuo, Yuri Ito, Atsumi Yanagisawa, Marie Ohbiki, Ken Tabuchi, Tatsuo Ichinohe, Yoshiko Hashii, Junya Kanda and 9 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Motohiro KatoDepartment of Pediatrics, The University of Tokyo, Tokyo, Japan. katom-tky@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-5145-1774
Hideki NakashoneDivision of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.ORCID http://orcid.org/0000-0001-5812-9315
Keitaro MatsuoDivision Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Yuri ItoDepartment of Medical Statistics, Research & Development Center, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Atsumi YanagisawaJapanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.
Marie OhbikiJapanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.ORCID http://orcid.org/0009-0007-3522-2278
Ken TabuchiJapanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.
Tatsuo IchinoheDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.ORCID http://orcid.org/0000-0002-0393-4066
Yoshiko HashiiDepartment of Pediatrics, Osaka International Cancer Institute, Osaka, Japan.
Junya KandaDepartment of Hematology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-6704-3633
Hideki GotoDivision of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
Koji KatoDepartment of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Makoto YoshimitsuDepartment of Hematology and Rheumatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.ORCID http://orcid.org/0000-0002-5935-0385
Atsushi SatoDepartment of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan.
Moeko HinoDepartment of Pediatrics, School of Medicine, Chiba University, Chiba, Japan.
Kimikazu MatsumotoNational Center for Child Health and Development, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5340-3781
Kimikazu YakushijinDepartment of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan.ORCID http://orcid.org/0000-0003-2511-7857
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.ORCID http://orcid.org/0000-0003-4404-2870
Takahiro FukudaDepartment of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.

Funding

National Center for Child Health and Development (NCCHD) 2022B-10
6 · The paper itself

Abstract

The impact of center volume on outcomes in pediatric hematopoietic cell transplantation (HCT) is not well established. We retrospectively analyzed data from a nationwide registry, including 6966 pediatric patients who underwent their first allogeneic HCT at 123 centers in Japan between 2001 and 2020. Centers were categorized by transplant volume as low volume centers (C1, the smallest number of transplantation), medium-low volume centers (C2), medium-high volume centers (C3), and high volume centers (C4, the greatest number of transplantation), and outcomes were compared across these categories. The analysis revealed no statistically significant differences in HCT outcomes among center categories. The 5-year OS by center category was 66.8% (95% CI 64.4-69.0%) for C1, 66.8% (95% CI 64.5-69.0%) for C2, 67.9% (95% CI 65.6-70.2%) for C3, and 68.3% (95% CI 65.9-70.6%) for C4. These results were consistent even when analysis was restricted to malignant and nonmalignant diseases. Our findings suggest that, unlike in adult HCT, outcomes for pediatric HCT are not significantly affected by center volume. These results indicate the consistent quality of care across centers, supporting the accessibility of HCT at various institutions for pediatric patients.

Indexed as

Hematopoietic Stem Cell TransplantationTransplantation ConditioningAdolescentAllograftsChildChild, PreschoolFemaleHumansInfantJapanMaleRegistriesRetrospective StudiesTransplantation, HomologousTreatment Outcome

Identifiers

PMID40211066
PMCPMC12151867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.