Evidence map›Paper›PMID 40211064›Full record

ArticleCell research2025

Structural basis of stepwise proton sensing-mediated GPCR activation.

Xiaolei Yue, Li Peng, Shenhui Liu, Bingjie Zhang, Xiaodan Zhang, Hao Chang, Yuan Pei, Xiaoting Li, Junlin Liu, Wenqing Shui and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaolei Yue *iHuman Institute, ShanghaiTech University, Shanghai, China.
Li Peng *iHuman Institute, ShanghaiTech University, Shanghai, China.
Shenhui Liu *iHuman Institute, ShanghaiTech University, Shanghai, China.
Bingjie ZhangiHuman Institute, ShanghaiTech University, Shanghai, China.
Xiaodan ZhangiHuman Institute, ShanghaiTech University, Shanghai, China.
Hao ChangiHuman Institute, ShanghaiTech University, Shanghai, China.
Yuan PeiiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0003-4065-2540
Xiaoting LiiHuman Institute, ShanghaiTech University, Shanghai, China.
Junlin LiuiHuman Institute, ShanghaiTech University, Shanghai, China.
Wenqing ShuiiHuman Institute, ShanghaiTech University, Shanghai, China.
Lijie WuiHuman Institute, ShanghaiTech University, Shanghai, China. wulj@shanghaitech.edu.cn.ORCID 0000-0002-2253-0497
Huji XuDepartment of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, Shanghai, China. huji_xu@tsinghua.edu.cn.ORCID 0000-0002-8588-118X
Zhi-Jie LiuiHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.ORCID 0000-0001-7279-2893
Tian HuaiHuman Institute, ShanghaiTech University, Shanghai, China. huatian@shanghaitech.edu.cn.ORCID 0000-0002-6132-2068

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32230026National Natural Science Foundation of China (National Science Foundation of China) 32271262
6 · The paper itself

Abstract

The regulation of pH homeostasis is crucial in many biological processes vital for survival, growth, and function of life. The pH-sensing G protein-coupled receptors (GPCRs), including GPR4, GPR65 and GPR68, play a pivotal role in detecting changes in extracellular proton concentrations, impacting both physiological and pathological states. However, comprehensive understanding of the proton sensing mechanism is still elusive. Here, we determined the cryo-electron microscopy structures of GPR4 and GPR65 in various activation states across different pH levels, coupled with G

Indexed as

ProtonsReceptors, G-Protein-CoupledCryoelectron MicroscopyHEK293 CellsHumansHydrogen-Ion ConcentrationModels, MolecularGPR4 protein, humanGPR65 protein, humanProtonsReceptors, G-Protein-Coupled

Identifiers

PMID40211064
PMCPMC12134361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.