Evidence map›Paper›PMID 40210989›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2025

A prospective study describing splanchnic NIRS and clinical outcomes in encephalopathic neonates receiving minimal enteral nutrition during therapeutic hypothermia.

Tatiana A Nuzum, Sean M Bailey, Martha Caprio, Elena V Wachtel

Registry-linked trialAbstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05471336 (A Prospective Study Describing Splanchnic NIRS Values in Infants With Neonatal Encephalopathy Undergoing Therapeutic Hypothermia and Receiving Enteral Feeds), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05471336 nacompletednot on this map

A Prospective Study Describing Splanchnic NIRS Values in Infants With Neonatal Encephalopathy Undergoing Therapeutic Hypothermia and Receiving Enteral Feeds

TypeinterventionalSponsorNYU Langone HealthRan2022 to 2024Enrolled40ConditionsNeonatal EncephalopathyArmsEnteral Feeding
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tatiana A NuzumDivision of Neonatology, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone, 550 1st Avenue, New York, NY, 10016, USA. tatiananuzum@rcsi.ie.ORCID http://orcid.org/0009-0000-5262-9626
Sean M BaileyDivision of Neonatology, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone, 550 1st Avenue, New York, NY, 10016, USA.
Martha CaprioDivision of Neonatology, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone, 550 1st Avenue, New York, NY, 10016, USA.
Elena V WachtelDivision of Neonatology, Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone, 550 1st Avenue, New York, NY, 10016, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare regional splanchnic oxygenation (SrSO2) levels and clinical outcomes between infants who received minimal enteral nutrition (MEN) during Therapeutic Hypothermia (TH), and those who did not. STUDY

designA prospective, interventional cohort study with a historic control group at two Regional Perinatal Centers (NCT05471336).

resultsParticipant demographics and clinical illness severity were similar between MEN (n = 40) and control (n = 40) groups. There were no significant safety events. SrSO2 levels were normal in both groups throughout. Subjects that received MEN experienced fewer central line days (5.8 v 6.9, p = 0.005) and higher rates of human milk feeding (77% v 46%, p = 0.010), and achieved full oral feeds sooner (9.9 v 13.4 days, p = 0.043).

conclusionSplanchnic tissue oxygenation was normal in both groups, and similar between groups throughout TH. Providing MEN during TH appears safe and effective, resulting in several important clinical benefits.

Indexed as

Enteral NutritionHypothermia, InducedHypoxia-Ischemia, BrainSplanchnic CirculationFemaleHumansInfant, NewbornMaleProspective StudiesSpectroscopy, Near-InfraredTreatment Outcome

Identifiers

PMID40210989

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.