Evidence map›Paper›PMID 40210882›Full record

ArticleScientific reports2025

Aquaporin 9 downregulation in KRAS

Yankui Liu, Jiahao Dou, Qi Tan, Shuning Chen, Yaru Li, Rong Wang, Ning Sun, Xiaowei Qi

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yankui Liu *Department of Pathology, Affiliated hospital of Jiangnan University, 1000, Hefeng Road, Wuxi, 214028, Jiangsu, China.
Jiahao Dou *Department of Pathology, Affiliated hospital of Jiangnan University, 1000, Hefeng Road, Wuxi, 214028, Jiangsu, China.
Qi Tan *Department of Pathology, Affiliated hospital of Jiangnan University, 1000, Hefeng Road, Wuxi, 214028, Jiangsu, China.
Shuning ChenDepartment of Pathology, Affiliated hospital of Jiangnan University, 1000, Hefeng Road, Wuxi, 214028, Jiangsu, China.
Yaru LiDepartment of Pathology, Affiliated hospital of Jiangnan University, 1000, Hefeng Road, Wuxi, 214028, Jiangsu, China.
Rong WangDepartment of Pathology, Affiliated hospital of Jiangnan University, 1000, Hefeng Road, Wuxi, 214028, Jiangsu, China.
Ning SunWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu, China. sunning@jiangnan.edu.cn.
Xiaowei QiDepartment of Pathology, Affiliated hospital of Jiangnan University, 1000, Hefeng Road, Wuxi, 214028, Jiangsu, China. qixiaowei97@126.com.

Funding

Project of Wuxi Translational Medicine Research Institution LCYJ202309
6 · The paper itself

Abstract

Patients with colorectal cancer (CRC) carrying KRAS mutations face a challenging prognosis, especially due to their reduced response to EGFR inhibitor therapies. Despite the use of drugs targeting the KRAS

Indexed as

ApoptosisAquaporinsColorectal NeoplasmsProto-Oncogene Proteins p21(ras)Cell Line, TumorCell ProliferationDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleMiddle AgedMolecular Docking SimulationMutationAQP9 protein, humanAquaporinsKRAS protein, humanProto-Oncogene Proteins p21(ras)AQP9Colorectal cancer (CRC)G12VKRASProliferationZHX2

Identifiers

PMID40210882
PMCPMC11986171

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.