ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025
H. pylori infection downregulates the expression and release of miR- 223 in neutrophils.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate the association between serum miR- 223 concentration and Helicobacter pylori (H. pylori) infection.
methodsH. pylori status was assessed using the Urea
resultsWe found that the relative expression level of miR- 223 in neutrophils from H. pylori-positive patients (20.35 ± 5.85) was significantly lower than that from healthy individuals (45.92 ± 10.59) (p < 0.05). Moreover, the expression level of miR- 7, which we selected as a control molecule, was not significantly lower in neutrophils from H. pylori-positive patients (3.07 ± 0.78) than healthy controls (4.43 ± 1.57) (p > 0.05), and the expression of miR- 7 was lower than miR- 223.
conclusionThese results indicated that circulating miR- 223 down-expression was of neutrophil origin in vitro and inversely associated with H. pylori infection.
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