Evidence map›Paper›PMID 40210777›Full record

ArticleArchives of virology2025

Genetic characterization of coronaviruses causing common cold symptoms based on micro-targeted capture sequencing.

Qiao Qiao, Xiaojuan Zhu, Zixinrong Meng, Hongbin Zhang, Tao Wu, Kangchen Zhao, Yiyue Ge, Lunbiao Cui

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiao Qiao *NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious Diseases, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, China.
Xiaojuan Zhu *NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious Diseases, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, China.
Zixinrong MengSchool of Public Health, Nanjing Medical University, Nanjing, 210009, China.
Hongbin ZhangJiangyin City Center for Disease Control and Prevention, Wuxi, 214400, China.
Tao WuNHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious Diseases, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, China.
Kangchen ZhaoNHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious Diseases, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, China.
Yiyue GeNHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious Diseases, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, China. geyiyue@jscdc.cn.
Lunbiao CuiNHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious Diseases, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, China. lbcui@jscdc.cn.ORCID http://orcid.org/0000-0001-6212-6053

Funding

National Key Research and Development Program of China 2023YFC2605100National Key Research and Development Program of China 2023YFC2605104Natural Science Foundation of Jiangsu Province BK20231374
6 · The paper itself

Abstract

A novel micro-targeted capture sequencing method was developed for four coronaviruses that cause common cold symptoms, and its sensitivity and clinical performance were assessed using 14 pharyngeal swab samples. This technique achieved 100% genomic coverage for samples with a cycle threshold (Ct) value of 32 or lower. The genotypes of the clinical isolates were determined by phylogenetic analysis, and unique mutations were identified in the receptor-binding domain (RBD) of the spike protein. Additional N-glycosylation sites were found in some of the isolates. This method offers a sensitive and rapid tool for genetic monitoring of common-cold coronaviruses and aids in their prevention and control.

Indexed as

Common ColdCoronavirusGenome, ViralGenotypeHumansMutationPhylogenySARS-CoV-2Spike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirus

Identifiers

PMID40210777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.