Evidence map›Paper›PMID 40210730›Full record

ArticleEuropean child & adolescent psychiatry2025

Neural activation during processing of emotional faces as a function of resilience in adolescents.

Steve Eaton, Harriet Cornwell, Jack Rogers, Stephane De Brito, Nicola Toschi, Christina Stadler, Nora Raschle, Kerstin Konrad, Gregor Kohls, Areti Smaragdi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Steve EatonDepartment of Psychology, University of Bath, 10 West, Bath, BA2 7AY, UK. eatons@cardiff.ac.uk.
Harriet CornwellDepartment of Psychology, University of Bath, 10 West, Bath, BA2 7AY, UK.
Jack RogersSchool of Psychology, University of Birmingham, Birmingham, UK.
Stephane De BritoSchool of Psychology, University of Birmingham, Birmingham, UK.
Nicola ToschiDepartment of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Christina StadlerJacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland.
Nora RaschleJacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland.
Kerstin KonradChild Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH, Aachen, Germany.
Gregor KohlsDepartment of Child and Adolescent Psychiatry, Faculty of Medicine, TUD Dresden University of Technology, German Center for Child and Adolescent Health (DZKJ), Partner site Leipzig/Dresden, Dresden, Germany.
Areti SmaragdiChild Development Institute, Toronto, Canada.
Karen Gonzalez-MadrugaDepartment of Child and Adolescent Psychiatry, King's College London, London, UK.
Maaike OosterlingDepartment of Psychology, University of Bath, 10 West, Bath, BA2 7AY, UK.
Anne MartinelliDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt Am Main, Germany.
Anka BernhardDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt Am Main, Germany.
Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt Am Main, Germany.
Catherine Hamilton-GiachritsisDepartment of Psychology, University of Bath, 10 West, Bath, BA2 7AY, UK.
Graeme FairchildDepartment of Psychology, University of Bath, 10 West, Bath, BA2 7AY, UK.

Funding

Medical Research Council MR/N0137941/1Seventh Framework Programme 602407
6 · The paper itself

Abstract

Neuroimaging studies suggest that resilience to adversity is linked to reduced emotional reactivity or enhanced emotion regulation. However, such studies are scarce and mainly use adult samples and categorical definitions of resilience. Using a novel, data-driven approach to define resilience dimensionally, based on cumulative adversity exposure across childhood and psychopathology, we investigated associations between resilience and brain activation during facial emotion processing in youth. We also tested for sex differences in the relationship between resilience and brain activation. fMRI data were acquired from 208 youths (aged 9-18 years; Mean age = 13.28), while viewing angry, fearful, and neutral faces. Whole-brain analyses were performed, followed by region-of-interest analyses focusing on the amygdala, hippocampus, and prefrontal cortex. Resilience was positively correlated with bilateral inferior frontal gyrus responses to fearful (versus neutral) faces, and negatively correlated with right superior temporal gyrus, left hippocampal, and right inferior frontal gyrus responses to neutral faces (versus fixation). Sex-by-resilience interactions were observed in the medial prefrontal cortex: males showed positive, while females showed negative, associations between resilience and brain activation, though these results did not survive correction for multiple comparisons. These findings provide further evidence that resilience in youth is associated with enhanced emotion regulation at a neural level.

Indexed as

BrainEmotional RegulationEmotionsFacial ExpressionFacial RecognitionResilience, PsychologicalAdolescentAmygdalaBrain MappingChildFemaleHippocampusHumansMagnetic Resonance ImagingMalePrefrontal CortexAdversityEmotionFace processingfMRIResilienceYouth

Identifiers

PMID40210730
PMCPMC12507940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.